81542-75-8

Upstream product

• 134958-69-3 DMT-dU-Bn 
• 14270-73-6 O^5'-trityl-2'-deoxy-uridine 
• 100-39-0 benzyl bromide 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 31281-28-4 2'-mercapto-2'-deoxyuridine 
• 208330-04-5 3'-O-benzyl-5'-O-trityl-2'-deoxyuridine 
• 132474-26-1 1-((3aR,4R,6R,6aR)-6-Hydroxymethyl-2-phenyl-tetrahydro-furo[3,4-d][1,3]oxathiol-4-yl)-1H-pyrimidine-2,4-dione 
• 23669-79-6 DMT-dU 

Downstream Products

• 134958-70-6 DMT-dTp(CH₃)dU-Bn 
• 208330-05-6 2,2-Dimethyl-propionic acid (2R,3S,5R)-3-[(2R,3S,5R)-3-benzyloxy-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 208330-08-9 C₃₁H₃₈N₄O₁₁ 
• 208330-06-7 C₃₁H₃₈N₄O₁₁ 
• 208330-07-8 C₃₁H₃₈N₄O₁₁ 

Relevant academic research and scientific papers

Synthesis, crystal structure, and enzymatic evaluation of a DNA-photolesion isostere

Nucleotide analogues are useful tools for the investigation of interactions between DNA-binding proteins and DNA at a molecular level. Herein we describe the synthesis of the DNA-lesion analogue 2, which is required to determine the extent to which specif

Unraveling the origin of the major mutation induced by ultraviolet light, the C→T transition at dTpdC sites. A DNA building block for the cis-syn cyclobutane dimer of dTpdU

One possible origin of the major mutation induced by ultraviolet light, the C→T transition at dTpdC sites, involves the replicative bypass of the cyclobutane dimer of dTpdC or its deamination product, the cis-syn dimer of dTpdU. In order to investigate the latter proposal, we have designed and synthesized a building block for the incorporation of the cis-syn dTpdU dimer into oligonucleotides by automated solid phase DNA synthesis technology.

A new procedure for the preparation of 3'-O-alkyl derivatives of 2'-deoxyribonucleosides

2'-Deoxy-2'-mercaptouridine (7) has been converted, via its 2'-S, 3'-O-alkylidene derivatives (8), into the corresponding 3'-O-alkyl-2'-deoxyuridines (9).