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Concanamycin B is a macrocyclic lactone antibiotic originally isolated from Streptomyces diastatochromogenes in 1982. It is a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A and inhibits vacuolar H(+)-ATPase, a proton pump enzyme found in various cellular compartments. This unique property makes it a valuable tool in various applications.

81552-33-2

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81552-33-2 Usage

Uses

Used in Pharmaceutical Industry:
Concanamycin B is used as an antibiotic and inhibitor of vacuolar-type H+-ATPase for its ability to inhibit the expression of newly-synthesized MHC class II molecules. This makes it a valuable tool in studying the immune system and developing new therapeutic strategies for various diseases.
Used in Immunology Research:
In immunology research, Concanamycin B is used as an inhibitor to study the role of vacuolar H(+)-ATPase in immune cell function. Its ability to suppress bone resorption in vitro also makes it a useful tool for investigating bone metabolism and related diseases.
Used in Cell Biology:
Concanamycin B is used in cell biology as a specific inhibitor of vacuolar H(+)-ATPase, allowing researchers to study the role of this enzyme in various cellular processes, such as endocytosis, exocytosis, and intracellular trafficking.
Overall, Concanamycin B's unique properties as an inhibitor of vacuolar H(+)-ATPase make it a valuable tool in various fields, including pharmaceuticals, immunology, and cell biology, for studying and developing new treatments for a wide range of diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 81552-33-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,5,5 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 81552-33:
(7*8)+(6*1)+(5*5)+(4*5)+(3*2)+(2*3)+(1*3)=122
122 % 10 = 2
So 81552-33-2 is a valid CAS Registry Number.
InChI:InChI=1/C45H73NO14/c1-13-15-33-27(6)36(57-37-21-32(47)42(31(10)56-37)59-44(46)52)22-45(53,60-33)30(9)40(50)29(8)41-34(54-11)17-14-16-23(2)18-25(4)38(48)28(7)39(49)26(5)19-24(3)20-35(55-12)43(51)58-41/h13-17,19-20,25-34,36-42,47-50,53H,18,21-22H2,1-12H3,(H2,46,52)/b15-13+,17-14+,23-16+,24-19+,35-20-/t25?,26-,27?,28+,29+,30?,31?,32?,33?,34?,36-,37?,38?,39-,40?,41?,42?,45?/m1/s1

81552-33-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name CONCANAMYCIN B

1.2 Other means of identification

Product number -
Other names ConcanaMycin B (high purity)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:81552-33-2 SDS

81552-33-2Upstream product

81552-33-2Downstream Products

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