81556-04-9Relevant academic research and scientific papers
Novel method for the synthesis of s -triazolo[3,4- b ][1,3,4]thiadiazines
El-Sherief, Hassan A. H.,Hozien, Zeniab A.,El-Mahdy, Ahmed F. M.,Sarhan, Abdelwareth A. O.
experimental part, p. 2636 - 2642 (2010/09/11)
The reaction of 4-amino-3-mercapto-5-phenyl-s-triazole with aromatic or aliphatic ketones containing active -hydrogens as a methyl or methylene group using an acidified acetic acid method afforded the corresponding s-triazolo[3,4-b][1,3,4]thiadiazines. In
Bicyclic Compounds Derived from 4-Amino-3-mercapto-1,2,4-triazoles: Facile Routes to 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazoles and 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazines
Heravi, M.M.,Rahimizadeh, M.,Seyf, M.,Davoodnia, A.,Ghassemzadeh, M.
, p. 211 - 218 (2007/10/03)
Treatment of 5-substituted-4-amino-3-mercapto-1,2,4-triazoles (1), with triethyl ortho-formate or acetyl chloride gave the corresponding triazolo[3,4-b]thiadiazoles (2) and (3), respectively. Reaction of (1) with phenacyl bromide, DMAD and DEAD afforded t
Ring Transformation of 1,3,4-Oxadiazole to s-Triazole-Fused Heterocycles. New Synthetic Route for Thiazolo-s-triazole and 7H-s-Triazolothiadiazine
Sasaki, Tadashi,Ito, Eikoh,Shimizu, Ikuo
, p. 2757 - 2760 (2007/10/02)
s-Triazole-fused heterocycles have been synthesized by an intramolecular transformation of some 1,3,4-oxadiazole ketones with ammonia or hydrazine.The α- ketone 2m gave thiazolo-s-triazole (4m), accompanied by a small amount of the hydrazide 9m on treatment with ammonium acetate in acetic acid.Similar treatment of ketones 2a and 2b afforded only the hydrazides 9a and 9b, respectively.Ketones 2a-n reacted with hydrazine hydrate in acetic acid to give 7H-s-triazolothiadiazines 5a-n.However, ketones 2o-q, with substituents α to the carbonyl group, could not be converted to the corresponding fused-ring systems.Mechanisms for these transformations are proposed.
