815575-60-1

Upstream product

• 6832-87-7 2-bromo-N-methylaniline 
• 16136-58-6 N-methyl-1H-indole-2-carboxylic acid 
• 118618-61-4 1-methyl-1H-indole-2-carbonyl chloride 
• 74-88-4 methyl iodide 
• 815575-57-6 1-methyl-1H-indole-2-carboxylic acid (2-bromo-phenyl)-amide 

Relevant academic research and scientific papers

Spirooxindole synthesis: Via palladium-catalyzed dearomative reductive-Heck reaction

Palladium-catalyzed intramolecular dearomative reductive-Heck reaction of C2-substituted indoles is developed, which provides access to structurally diverse 3,2′-spiropyrrolidine oxindoles. By changing the hydride source to AcONa base, direct C3-arylation

Radical dearomatising spirocyclisations onto the C-2 position of benzofuran and indole

New spirolactams were obtained in radical dearomatising spirocyclisations of alkyl, vinyl and aryl radicals tethered at the C-2 positions of benzofuran and indole. Spirolactams were obtained via an intramolecular radical ipso-type spirocyclisation in benzofuran and indole systems. Alkyl, vinyl and aryl radicals, tethered at the C-2 position of the heterocycle underwent radical cyclisation to produce novel tricyclic partially dearomatised heterocycles in moderate yields. Fragmentation of the furan ring was observed subsequent to spirocyclisation of a vinyl radical onto a benzofuran.