81559-79-7Relevant academic research and scientific papers
The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating
Baxendale, Ian R.,Ley, Steven V.,Martinelli, Marisa
, p. 5323 - 5349 (2007/10/03)
Herein, we report on the preparation of a library of 5-substituted-2-amino- 1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-aminosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products.
A Reinvestigation of the Cyclodesulfurization of Thiosemicarbazides
Sunder, Shyam,Peet, Norton P.,Barbuch, Robert J.
, p. 1601 - 1604 (2007/10/02)
A recent report describing the preparation of 2-(substituted-amino)-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones (3), by the cyclodesulfurization of hydrazides prepared from o-aminobenzoylhydrazine (1) and isothiocyanates, is erroneous.The products resulting from this reaction sequence are, instead 2-(substituted-amino)-5-(o-aminophenyl)-1,3,4-oxadiazoles (4).Alternate synthesis of the oxadiazoles led to the correct structural assignments.
