815600-27-2

Upstream product

• 131685-53-5 (S)-4-benzyl-3-propionyl-2-oxazolidinone 
• 263543-10-8 (R)-3-(tert-butyldimethylsilyloxy)-4-methoxybutanal 
• 819849-59-7 tert-butyl-[3-(4-methoxy-benzyloxy)-1-methoxymethyl-propoxy]-dimethyl-silane 
• 276248-86-3 (R)-4-Methoxymethyl-2-(4-methoxy-phenyl)-[1,3]dioxane 
• 276248-87-4 (R)-1-Methoxy-4-(4-methoxy-benzyloxy)-butan-2-ol 

Downstream Products

• 815600-30-7 (2R,3S,4R,5R,7R)-1-[(4R,5S)-5-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-7-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-8-methoxy-5-(4-methoxy-benzyloxy)-2,4-dimethyl-octan-1-one 
• 815600-33-0 (2R,3R,4S,5S,6R)-2-[(4R,5S)-5-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propyl]-2-methoxy-3,5-dimethyl-tetrahydro-pyran 
• 815600-29-4 (2S,3R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoic acid methoxy-methyl-amide 
• 815600-20-5 (2S,3R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanal 

Relevant academic research and scientific papers

Synthetic studies on apoptolidin: Synthesis of the C12-C28 fragment via a highly stereoselective aldol reaction

The stereoselective and convergent synthesis of the C12-C28 segment 2 of the apoptosis inducing macrolide antibiotic, apoptolidin (1), is described. The synthesis involves a highly stereoselective tin(II)-mediated aldol reaction between the C17-C22 ethyl