81561-74-2

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 1023921-76-7 1-(3-trifluoromethylphenyl)-2-(p-tolylsulfonyloxy)ethanone 

Downstream Products

• 81422-99-3 (R)-2-(3-(trifluoromethyl)phenyl)oxirane 
• 1613040-98-4 (S,Z)-2-(3-(trifluoromethyl)phenyl)pent-3-en-1-ol 
• 1613041-28-3 (3R,5S)-3-methyl-5-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-2-one 
• 1613041-29-4 (3S,5S)-3-methyl-5-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-2-one 
• 1613041-30-7 (3R,4S)-3-ethyl-4-(3-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one 
• 1613041-31-8 (3S,4S)-3-ethyl-4-(3-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

Distal-selective hydroformylation using scaffolding catalysis

In hydroformylation, phosphorus-based directing groups have been consistently successful at placing the aldehyde on the carbon proximal to the directing group. The design and synthesis of a novel catalytic directing group are reported that promotes aldehyde formation on the carbon distal relative to the directing functionality. This scaffolding ligand, which operates through a reversible covalent bond to the substrate, has been applied to the diastereoselective hydroformylation of homoallylic alcohols to afford δ-lactones selectively. Altering the distance between the alcohol and the olefin revealed that homoallylic alcohols gives the distal lactone with the highest levels of regioselectivity.

Enantioselective synthesis of 1-arylethanediols by rhodium-catalyzed transfer hydrogenation of α-tosyloxyarylketones

Catalytic transfer hydrogenation of α-tosyloxyarylketones mediated by a chiral rhodium complex using an azeotropic mixture of formic acid/triethylamine afforded the corresponding 1-arylethanediol monotosylates in excellent yield with high enantioselectivity.

METHOD FOR THE PREPARATION OF OPTICALLY ACTIVE 2-SULFONYLOXY-1-PHENYLETHANOL DERIVATIVES

Optically active 2-sulfonyloxy-1-phenylethanol derivative of formula (II) can be prepared easily and selectively by the method of the present invention using an asymmetric reduction of an α-sulfonyloxy acetophenone compound with a rhodium catalyst having petamethylcyclopentadienyl group and a hydrogen donor, and the compound of formula (II) obtained in the inventive method exhibits a higher e.e. (enantiomer excess) value than that of the products in the conventional methods.

Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions

Compounds of formula (II): STR1 or a pharmaceutically acceptable salt thereof, in which X is an oxygen atom or a bond, R1 is a hydrogen, fluorine, chlorine or bromine atom or a trifluoromethyl or C1-4 alkyl group, each of R2 and R3 is a hydrogen atom or a C1-4 alkyl group, R4 is a C1-4 alkyl group, R5 is a hydrogen atom or a C1-4 alkyl group, and n is an integer of from 1 to 3; are useful as anti-obesity and/or anti-hyperglycaemic agents.