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Usage

Uses

Used in Pharmaceutical Applications:
2-Iodothiobenzamide is utilized as an inhibitor of the enzyme carbonic anhydrase for its potential therapeutic effects in various medical conditions. Its ability to inhibit this enzyme is significant in the treatment of glaucoma, epilepsy, and altitude sickness, as it can help manage the symptoms and progression of these diseases.
Used in Research:
In the field of medicinal chemistry, 2-iodothiobenzamide is employed as a subject of ongoing research. Its unique properties and potential biological activity make it valuable for the development of new drugs and understanding its broader implications in medicine.
Used in Drug Development:
2-Iodothiobenzamide is also used as a component in the development of new pharmaceuticals. Its potential to inhibit carbonic anhydrase and other biological activities make it a key player in creating innovative treatments for a variety of health issues.

InChI:InChI=1/C7H6INS/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H2,9,10)

Upstream product

• 4387-36-4 2-iodobenzonitrile 
• 3930-83-4 o-iodobenzamide 

Downstream Products

• 1620790-06-8 ethyl 2-(2-iodophenyl)thiazole-4-carboxylate 
• 1620790-14-8 ethyl 4-(2-iodophenyl)thiazole-2-carboxylate 

Relevant academic research and scientific papers

Method for synthesizing thiobenzamide derivative through CO2 regulation and control of substituted benzonitrile

The invention discloses a method for synthesizing a thiobenzamide derivative through CO2 regulation and control of substituted benzonitrile. The method comprises the following steps: taking the substituted benzonitrile as a raw material, an inorganic sulfide as a sulfur source and CO2 as an auxiliary agent for reacting in the presence of a reaction solvent, and concentrating and purifying a reaction solution to obtain the thiobenzamide derivative. The reaction system disclosed by the invention is relatively simple, other catalysts are not added outside a reactant and the inorganic sulfide, themethod is suitable for synthesis of high-additional-value thiobenzamide containing a plurality of substituent groups, the reaction is carried out at low temperature and low pressure, and the risk coefficient is reduced.

Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets

Chemoprevention is an approach to decrease cancer morbidity and mortality through inhibition of carcinogenesis and prevention of disease progression. Although the trans stilbene derivative resveratrol has chemopreventive properties, its action is compromised by weak non-specific effects on many biological targets. Replacement of the stilbene ethylenic bridge of resveratrol with a 1,2,4-thiadiazole heterocycle and modification of the substituents on the two aromatic rings afforded potential chemopreventive agents with enhanced potencies and selectivities when evaluated as inhibitors of aromatase and NF-κB and inducers of quinone reductase 1 (QR1).

The Loss of ortho Halogeno Substituents From Substituted Thiobenzamide Ions

The loss of ortho substituents (CH3, Cl, Br, I) from molecular ions of substituted thiobenzamides has been investigated by determination of the critical energy and kinetic energy released during this process to obtain some further insight into the corresponding reaction of N,N-dimethylthiobenzamide ions.In contrast to the latter compounds the ortho methyl substituent is not eliminated from the molecular ions of o-methylthiobenzamide, but the loss of ortho halogeno substituents occurs with identical reaction characteristics in both series of compounds.It is concluded that the loss of halogeno substituents from molecular ions in both series corresponds to a direct substitution reaction via a 4-membered transition state.