81572-09-0Relevant academic research and scientific papers
Metal-Free Oxidative Decarbonylative Coupling of Aliphatic Aldehydes with Azaarenes: Successful Minisci-Type Alkylation of Various Heterocycles
Tang, Ren-Jin,Kang, Lei,Yang, Luo
supporting information, p. 2055 - 2060 (2015/06/23)
A metal-free oxidative decarbonylative coupling of aliphatic aldehydes with various electron-deficient heterocycles has been developed. This reaction is supposed to be realized via a Minisci-type mechanism, based on the substrate scope, regioselectivity and radical trapping experiments. The ready availability of aliphatic aldehydes, metal-free conditions and broad substrate scope should make this method attractive for the late-stage alkylation of bioactive heterocycles.
Palladium-catalysed synthesis of pyrimidines
Ingebrigtsen, Truls,Helland, Irene,Lejon, Tore
, p. 2593 - 2603 (2007/10/03)
Satisfactory yields of 4-substituted pyrimidines and bicyclic pyrimidines are produced from α-methyl or α-methylene ketones when reacted with formamide and tetrakis(triphenylphosphine)palladium(0) or a 1:2 mixture of palladium(II) acetate and triphenylphosphine as catalysts. Under the same reaction conditions pyridines or imidazole are formed from 1,3- or 1,2-diketones.
Synthesis of pyrimidines from ketones using microwave irradiation
Tyagarajan, Sriram,Chakravarty, Prasun K.
, p. 7889 - 7891 (2007/10/03)
A simple, high yielding synthesis of pyrimidines from ketones in the presence of HMDS and formamide is described. Under microwave irradiation, heteroaromatic, aryl, aliphatic, and cyclic ketones cyclized to give pyrimidines in good yields.
