81576-47-8

Usage

Uses

Used in Pharmaceutical Industry:
(S,R)-N-(1-Phenylethyl) Ibuprofen AMide is used as an impurity in the synthesis of Ibuprofen for anti-inflammatory applications. Its presence in the synthesis process can affect the purity and efficacy of the final product, making it an important compound to monitor and control during manufacturing.
Used in Research and Development:
(S,R)-N-(1-Phenylethyl) Ibuprofen AMide is used as a research compound to study the effects of stereochemistry on the biological activity of Ibuprofen and other related drugs. This can lead to the development of more effective and targeted therapies for inflammatory conditions.
Used in Quality Control:
(S,R)-N-(1-Phenylethyl) Ibuprofen AMide is used in quality control processes to ensure the purity and consistency of Ibuprofen products. By testing for the presence and quantity of this impurity, manufacturers can maintain high standards of product quality and safety.

Upstream product

• 15687-27-1 ibuprofen 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 898527-80-5 2-(4-isobutylphenyl)-N-[(trifluoromethyl)sulfonyl]propanamide 
• 34645-72-2 (RS)-2-(4'-iodophenyl)propanoic acid 
• 51146-56-6 (S)-ibuprofen 
• 76099-91-7 (S)-(+)-2-(4'-iodophenyl)propanoic acid 
• 107672-16-2 (S)-2-(4'-<2-methyl-1-propenyl>phenyl)propanoic acid 
• 51146-57-7 (R)-ibuprofene 
• 152140-57-3 (R)-2-(4-iodophenyl)propanoic acid 
• 618-36-0 rac-methylbenzylamine 
• 859827-67-1 (2R)-2-(4-isobutylphenyl)-N-[(trifluoromethyl)sulfonyl]propanamide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Relevant academic research and scientific papers

BORONIC ACID CATALYSTS AND METHODS OF USE THEREOF FOR ACTIVATION AND TRANSFORMATION OF CARBOXYLIC ACIDS

The present application provides methods and catalysts for activation of carboxylic acids for organic reactions. In particular, methods are disclosed for direct nucleophilic addition reactions, such as, amidation reactions with amines, cycloadditions, and conjugate additions, using boronic acid catalysts of formula I, II or III: Also included are novel boronic acid catalysts of formula IV, V and III:

Direct and waste-free amidations and cycloadditions by organocatalytic activation of carboxylic acids at room temperature

(Chemical Equation Presented) Taming carboxylic acids: ortho-Iodo- and ortho-bromophenylboronic acids are exceptional organocatalysts in atom-economical amidations between free carboxylic acids and amines, including functionalized ones, and can also provide LUMO-lowering activation in [4 + 2] cycloadditions of α,β-unsaturated carboxylic acids.

N-Acyltrifluoromethanesulfonamides as new chemoselective acylating agents for aliphatic and aromatic amines

This work describes advances in the study of the internal condensation of ammonium salts of N-acylsulfonamides. N-Acyltrifluoromethanesulfonamides show considerable advantages over the non fluorinated analogues by virtue of their higher reactivity and aci

Synthesis of Arylpropanoic Acids From Optically Active 2-(Iodophenyl)propanoic Acids

The coupling of organozinc compounds with homochiral 2-(3-iodophenyl)propanoic and 2-(4-iodophenyl)propanoic acids in the presence of palladium is a general method for the synthesis of optically active arylpropanoic acids.