81576-52-5

Usage

Uses

Used in Pharmaceutical Industry:
(S,S)-N-(1-Phenylethyl) Ibuprofen AMide is used as an anti-inflammatory agent for its potential to modulate inflammatory pathways and alleviate pain and swelling. The chiral nature of (S,S)-N-(1-Phenylethyl) Ibuprofen AMide may provide improved selectivity and reduced side effects compared to the racemic mixture of ibuprofen.
Used in Drug Development:
(S,S)-N-(1-Phenylethyl) Ibuprofen AMide can be utilized in drug development as a lead compound for the synthesis of novel anti-inflammatory and analgesic drugs. Its unique structure may offer new opportunities for the design of more effective and safer medications.
Used in Research:
(S,S)-N-(1-Phenylethyl) Ibuprofen AMide can be employed in research settings to study the effects of chirality on drug efficacy and safety. It may also be used to investigate the role of specific molecular modifications in enhancing the pharmacological properties of ibuprofen and related drugs.

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 51146-56-6 (S)-ibuprofen 
• 15687-27-1 ibuprofen 
• 898527-80-5 2-(4-isobutylphenyl)-N-[(trifluoromethyl)sulfonyl]propanamide 
• 859827-67-1 (2R)-2-(4-isobutylphenyl)-N-[(trifluoromethyl)sulfonyl]propanamide 
• 618-36-0 rac-methylbenzylamine 
• 152140-57-3 (R)-2-(4-iodophenyl)propanoic acid 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 51146-57-7 (R)-ibuprofene 
• 107672-16-2 (S)-2-(4'-<2-methyl-1-propenyl>phenyl)propanoic acid 
• 76099-91-7 (S)-(+)-2-(4'-iodophenyl)propanoic acid 
• 34645-72-2 (RS)-2-(4'-iodophenyl)propanoic acid 

Relevant academic research and scientific papers

BORONIC ACID CATALYSTS AND METHODS OF USE THEREOF FOR ACTIVATION AND TRANSFORMATION OF CARBOXYLIC ACIDS

The present application provides methods and catalysts for activation of carboxylic acids for organic reactions. In particular, methods are disclosed for direct nucleophilic addition reactions, such as, amidation reactions with amines, cycloadditions, and conjugate additions, using boronic acid catalysts of formula I, II or III: Also included are novel boronic acid catalysts of formula IV, V and III:

Direct and waste-free amidations and cycloadditions by organocatalytic activation of carboxylic acids at room temperature

(Chemical Equation Presented) Taming carboxylic acids: ortho-Iodo- and ortho-bromophenylboronic acids are exceptional organocatalysts in atom-economical amidations between free carboxylic acids and amines, including functionalized ones, and can also provide LUMO-lowering activation in [4 + 2] cycloadditions of α,β-unsaturated carboxylic acids.

N-Acyltrifluoromethanesulfonamides as new chemoselective acylating agents for aliphatic and aromatic amines

This work describes advances in the study of the internal condensation of ammonium salts of N-acylsulfonamides. N-Acyltrifluoromethanesulfonamides show considerable advantages over the non fluorinated analogues by virtue of their higher reactivity and aci

Synthesis of Arylpropanoic Acids From Optically Active 2-(Iodophenyl)propanoic Acids

The coupling of organozinc compounds with homochiral 2-(3-iodophenyl)propanoic and 2-(4-iodophenyl)propanoic acids in the presence of palladium is a general method for the synthesis of optically active arylpropanoic acids.