81622-74-4

Upstream product

• 5541-64-0 2-(4-nitro-phenyl)-quinoxaline 
• 17286-66-7 N-[4-(quinoxalin-2-yl)phenyl]acetamide 
• 1448-87-9 2-chloroquinoxaline 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 95-54-5 1,2-diamino-benzene 
• 23442-14-0 4-aminophenacyl bromide 
• 99-81-0 4-Nitrophenacyl bromide 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 67014-06-6 N-(4-(2-oxoacetyl)phenyl)acetamide 

Downstream Products

• 855933-25-4 N-acetyl-sulfanilic acid-(4-quinoxalin-2-yl-anilide) 

Relevant academic research and scientific papers

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof

The present invention relates to novel hydrazone derivatives with an aryl or heteroaryl group substituted at a terminal amine group thereof and a use thereof.

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae (I) (II) (III) (IV), wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

AMIDO COMPOUNDS AS AhR MODULATORS

Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

Recyclable acidic br?nsted ionic liquid catalyzed synthesis of quinoxaline

The acidic ionic liquid, 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate [MimC4SO3H]HSO4 catalyzed two-component condensation reaction of phenacyl bromide and o-phenylenediamine to afford corresponding quinoxaline derivatives. The inexpensive and non-toxic ionic liquids can be reused several times without any perceptible loss of their activities.

Synthesis of quinoxaline using silica supported phosphomolybdic acid as reusable heterogeneous catalyst

Using phosphomolybdic acid on silica as recyclable catalyst we have developed methodology for the synthesis of quinoxalines by condensation of phenacyl bromides and o-phenylene diamines in ClCH2CH2Cl at 80°C. The phosphomolybdic acid