23442-14-0

Usage

Uses

Used in Chemical Synthesis:
4'-AMINOPHENACYL BROMIDE is used as a synthetic intermediate for the preparation of various chemical compounds, particularly in the field of organic chemistry. Its unique structure allows for further functionalization and modification, making it a versatile building block for the synthesis of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4'-AMINOPHENACYL BROMIDE is used as a key component in the synthesis of novel VO(II)-triazole complexes. These complexes have potential applications in various therapeutic areas, including the development of new drugs with improved efficacy and selectivity.
Used in Material Science:
4'-AMINOPHENACYL BROMIDE can also be utilized in the field of material science, where it may contribute to the development of new materials with specific properties. Its reactivity and structural features make it a valuable component in the design and synthesis of advanced materials for various applications, such as sensors, catalysts, and optoelectronic devices.

InChI:InChI=1/C8H8BrNO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5,10H2

Upstream product

• 103-84-4 Acetanilid 
• 21675-02-5 4-acetylaminophenacyl bromide 
• 99-81-0 4-Nitrophenacyl bromide 
• 99-92-3 p-aminobenzophenone 

Downstream Products

• 99068-47-0 (4-amino-phenacylmercapto)-acetic acid amide 
• 110841-97-9 4-(4-Amino-phenyl)-3-phenyl-1,5-dihydro-pyrrol-2-one 
• 110842-01-8 4-(4-Amino-phenyl)-3-(4-nitro-phenyl)-1,5-dihydro-pyrrol-2-one 
• 1026837-71-7 4-(6,6-Dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-2-yl)-phenylamine 
• 73932-42-0 1-(4-aminophenyl)-2-(1H-imidazol-1-yl)ethanone 
• 879-37-8 3-indolylacetamide 
• 34778-57-9 tridecanoic acid[2,6-diethyl-2,3,6-trimethyl-1-(1-phenyl-ethoxy)-piperidin-4-yl]-amide 
• 26476-16-4 1-tetrazolylacetamide 
• 621-88-5 phenoxyacetamide 
• 156897-13-1 [2-(4-Amino-phenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]-acetic acid 
• 1026170-67-1 [2-(4-Amino-phenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Alkoxy pyridone compound as well as preparation method and application thereof

The invention belongs to the field of medicinal chemistry, specifically, the invention relates to a series of inhibitors of factor XIa (FXIa for short) with a novel structure as well as a preparationmethod and an application thereof. The structure is shown as the following general formula (I). These compounds or stereoisomers, racemates, geometric isomers, tautomers, prodrugs, hydrates, solvatesor pharmaceutically acceptable salts and pharmaceutical compositions thereof can be used to treat or/and prevent related diseases mediated by factor XIa (FXIa for short).

Hydrogenation of nitroaromatics to anilines catalyzed by air-stable arene ruthenium (II)–NNN pincer complexes

A series of air-stable, phosphine-free arene ruthenium (II)–NNN pincer complexes (RuL, RuL1, RuL2 and RuL3) have been synthesized and characterized by spectroscopic and single-crystal X-ray analysis. Further, arene ruthenium (II)–NNN pincer complexes have been used as catalyst for hydrogenation of nitroaromatics into aniline in the presence of NaBH4 at room temperature. The catalytic process suggested highly chemo-selective nitroreduction with wide functional group tolerance.

Dehydrozingerone Inspired Styryl Hydrazine Thiazole Hybrids as Promising Class of Antimycobacterial Agents

Series of styryl hydrazine thiazole hybrids inspired from dehydrozingerone (DZG) scaffold were designed and synthesized by molecular hybridization approach. In vitro antimycobacterial activity of synthesized compounds was evaluated against Mycobacterium tuberculosis H37Rv strain. Among the series, compound 6o exhibited significant activity (MIC = 1.5 μM; IC50 = 0.48 μM) along with bactericidal (MBC = 12 μM) and intracellular antimycobacterial activities (IC50 = 0.098 μM). Furthermore, 6o displayed prominent antimycobacterial activity under hypoxic (MIC = 46 μM) and normal oxygen (MIC = 0.28 μM) conditions along with antimycobacterial efficiency against isoniazid (MIC = 3.2 μM for INH-R1; 1.5 μM for INH-R2) and rifampicin (MIC = 2.2 μM for RIF-R1; 6.3 μM for RIF-R2) resistant strains of Mtb. Presence of electron donating groups on the phenyl ring of thiazole moiety had positive correlation for biological activity, suggesting the importance of molecular hybridization approach for the development of newer DZG clubbed hydrazine thiazole hybrids as potential antimycobacterial agents.

INHIBITORS OF HISTONE DEACETYLASE

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula (I), (II), (IIa), (III), (IV), (V), or (VI)) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.

Synthesis of α-bromoalkanones using urea-hydrogen peroxide complex and sodium bromide over silica gel-acetic acid

α-Bromoalkanones 2 have been synthesized by the reaction of alkanones 1 with UHP-NaBr over SiO2-acetic acid in solvent-free conditions under microwave irradiation.

Kinetics of bromination of substituted acetophenones by phenyltrimethylammonium tribromide

Bromination of different ketones in glacial acetic acid by phenyltrimethylammonium tribromide (PTT) using sulfuric acid as catalyst at different temperature has been carried out. The study shows first order kinetics due to ketones and inverse first order kinetics due to PTT. The thermodynamic parameters are evaluated. The products of bromination of different acetophenones are found to be monobromoacetophenones.