81625-24-3Relevant academic research and scientific papers
Consecutive reactions to construct tricarbonyl compounds and synthetic applications thereof
Madro?ero, Diego,Mujica-Martinez, Cesar A.,Vázquez, Alfredo
, p. 33235 - 33244 (2021/12/09)
Lithium anions derived from O-carbonate-protected cyanohydrins undergo conjugate addition to cycloalkenones with the concomitant transfer of the alkoxycarbonyl group to produce tricarbonyl compounds. These products offer numerous possibilities for further
Efficient synthesis in water of mixed carbonates of cyanohydrins from aromatic aldehydes
Héctor Manuel, Torres Domínguez,Luis ángel, Maldonado,Ronan, Le Lagadec
supporting information, (2019/12/11)
An efficient preparation of cyanohydrin ethyl carbonates via cyanocarbonation of aromatic and hetero-aromatic aldehydes with sodium cyanide and ethyl chlorocarbonate using commercial surfactants (5 mol %) in aqueous media at low temperature afforded almos
Tuning the Catalytic Activity of Tertiary-Amine Functionalized Polyacrylonitrile Fibers by Adjusting the Surface Microenvironment
Li, Pengyu,Liu, Yuanyuan,Cao, Jian,Tao, Minli,Zhang, Wenqin
, p. 3725 - 3732 (2017/10/16)
Polyacrylonitrile fibers were functionalized with different amines to construct special tridimensional catalytic microenvironments at the surface. The polarity of the microenvironments at the surface of the fiber catalyst was tuned by changing the ratio o
N-heterocyclic carbene catalyzed cyanation reaction of carbonyl compounds with ethyl cyanoformate and acetyl cyanide
Zhang, Jie,Du, Guangfen,Xu, Yueke,He, Lin,Dai, Bin
supporting information; experimental part, p. 7153 - 7156 (2012/01/05)
N-heterocyclic carbene (NHC) has been employed as an efficient catalyst for cyanation reaction of carbonyl compounds. Under catalysis of 1 mol % NHCs, various aldehydes and 2,2,2-trifluoroacetophenone coupled with ethyl cyanoformate in THF to provide cyanohydrins ethyl carbonates in excellent yields. While in the presence of 10 mol % catalyst, different types of aldehydes and 2,2,2-trifluoroacetophenone reacted with acetyl cyanide in dichloroethane to give acylated cyanohydrins in moderate to high yields.
N,N-Dimethylpyridin-4-Amine mediated protocol for cyanoethoxycarbonylation of aldehydes under solvent-free conditions
Khan, Noor-Ul H.,Agrawal, Santosh,Kureshy, Rukhsana I.,Bera, Prasanta K.,Abdi, Sayed H.R.,Bajaj, Hari C.
experimental part, p. 255 - 260 (2010/11/05)
N,N-Dimethylpyridin-4-amine(DAMP)(10 mol%) was successfully employed as catalyst for cyanoethoxycarbonylation of aromatic and aliphatic aldehydes at room temperature under solvent free condition to give corresponding ethylcyanocarbonates in excellent isol
Ionic liquid as catalytic and reusable media for cyanoethoxycarbonylation of aldehydes
Khan, Noor-Ul H.,Agrawal, Santosh,Kureshy, Rukhsana I.,Abdi, Sayed H.R.,Sadhukhan, Arghya,Pillai, Renjith S.,Bajaj, Hari C.
experimental part, p. 907 - 912 (2010/10/03)
Various ionic liquids (IL 1-9) based on N-methyl N'-alkyl imidazolium salts were explored as catalytic media in cyanoethoxycarbonylation of various aldehydes. The study revealed that the alkyl chain length and counter ion of the ionic liquid are critical
Synthesis of aryl α-keto esters via the rearrangement of aryl cyanohydrin carbonate esters
Thasana, Nopporn,Prachyawarakorn, Vilailak,Tontoolarug, Sopchok,Ruchirawat, Somsak
, p. 1019 - 1021 (2007/10/03)
A facile synthesis of aryl α-keto esters is reported involving the rearrangement of aryl cyanohydrin carbonate esters induced by the α-carbanion to the nitrile group generated by LDA. However, under similar conditions, an o-benzyloxycyanohydrin carbonate ester rearranged via a domino reaction leading to 2-phenylbenzofuran-3-carboxylic acid.
Synthesis of 1,2,3,4-Tetrahydroisoquinolines
Kashdan, David S.,Schwartz, John A.,Rapoport, Henry
, p. 2638 - 2643 (2007/10/02)
Several aspects of 1,2,3,4-tetrahydroisoquinoline synthesis have been examined.An improved synthesis of 2-(m-methoxyphenyl)ethylamine (4) is reported. m-Anisaldehyde (5) was treated with potassium cyanide and ethyl chloroformate to yield O-(ethoxycarbonyl)-3-methoxymandelonitrile (7).Hydrogenation afforded 2-(m-methoxyphenyl)ethylamine (4) in 87percent yield overall.Some observations have been made regarding the reduction of 3,4-dihydroisoquinolines derived from the Bischler-Napieralski reaction.Amides 3a and 3c were cyclized with phosphorus oxychloride, followed by reduction to the corresponding tetrahydroisoquinolines 1a and 1c.It was shown that 1a and 1c were contaminated with 4percent of 2a and 3percent of 2c, respectively.Both 2a and 2c were independently synthesized by routes with general applicability to 8-alkoxy-1,2,3,4-tetrahydroisoquinolines.
