816429-66-0

Upstream product

• 76-83-5 trityl chloride 
• 951-78-0 L-Deoxyuridine 

Downstream Products

• 207128-21-0 1-((2S,4R,5S)-4-Fluoro-5-trityloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 
• 207128-18-5 1-((2S,4S,5S)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 
• 207128-22-1 β-2',3'-dideoxy-3'-fluoro-L-uridine 
• 177365-14-9 β-L-2',3'-dideoxy-3'-fluorocytidine 
• 207128-16-3 Methanesulfonic acid (2S,3R,5S)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Methods of manufacture of 2'-deoxy-beta-L-nucleosides

The present invention relates to the synthesis of 2′-deoxy-β-L-thymidine, 2′-deoxy-β-L-uridine and 2′-deoxy-β-L-cytidine, and their derivatives, such as the 3′-O-acyl or 3′,5′-O-diacyl prodrugs, including the 3′-O-L-aminoacyl and 3′,5′-O-L-diaminoacyl prodrugs, and particularly the 3′-O-L-valinyl and 3′,5′-O-L-divalinyl prodrugs.

Newly synthesized L-enantiomers of 3'-fluoro-modified β-2'- deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases α, β, Γ, δ, and ε nor HIV-1 reverse transcriptase

Novel β-L-2',3'-dideoxy-3'-fluoro nucleosides were synthesized and further converted to their 5'-triphosphates. Their inhibitory activities against hepatitis B virus (HBV) and duck hepatitis B virus (DHBV) DNA polymerases, α, ?, γ, δ and ε were investigat