81644-34-0

Basic information

• Product Name: (6beta,17alpha,22R)-6,14,17,20-tetrahydroxy-22,26-epoxyergosta-2,4,24-triene-1,26-dione
• Synonyms: Withaperuvin C;Ergosta-2,4,24-trien-26-oic acid, 6,14,17,20,22-pentahydroxy-1-oxo-, δ-lactone, (6β,17α,22R)-
• CAS NO: 81644-34-0
• Molecular Formula: C₂₈H₃₈O₇
• Molecular Weight: 486.5971
• Mol File: 81644-34-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 711.367°C at 760 mmHg
• Flash Point: 235.756°C
• Density: 1.33g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.62
• PKA: 13.71±0.29(Predicted)
• CAS DataBase Reference: (6beta,17alpha,22R)-6,14,17,20-tetrahydroxy-22,26-epoxyergosta-2,4,24-triene-1,26-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (6beta,17alpha,22R)-6,14,17,20-tetrahydroxy-22,26-epoxyergosta-2,4,24-triene-1,26-dione(81644-34-0)
• EPA Substance Registry System: (6beta,17alpha,22R)-6,14,17,20-tetrahydroxy-22,26-epoxyergosta-2,4,24-triene-1,26-dione(81644-34-0)

Safety Data

• Hazardous Substances Data: 81644-34-0(Hazardous Substances Data)

Usage

Description

(6beta,17alpha,22R)-6,14,17,20-tetrahydroxy-22,26-epoxyergosta-2,4,24-triene-1,26-dione is a complex chemical compound derived from ergosterol, a sterol found in fungi. It features multiple hydroxyl groups and a unique epoxy ring structure, which may contribute to its observed anti-inflammatory and anti-cancer activities. This molecule holds promise as a potential drug candidate for the treatment of various inflammatory and cancer-related conditions, although further research is necessary to fully understand its therapeutic potential and mechanism of action.

Uses

Used in Pharmaceutical Industry:
(6beta,17alpha,22R)-6,14,17,20-tetrahydroxy-22,26-epoxyergosta-2,4,24-triene-1,26-dione is used as a potential drug candidate for the treatment of [application reason] due to its demonstrated anti-inflammatory and anti-cancer activities.
Used in Research and Development:
In the field of research and development, (6beta,17alpha,22R)-6,14,17,20-tetrahydroxy-22,26-epoxyergosta-2,4,24-triene-1,26-dione is used as a subject of study to explore its therapeutic potential and mechanism of action, with the aim of developing new treatments for inflammatory and cancer-related conditions.

Upstream product

• 38254-15-8 (+)-withanolide E 
• 108030-78-0 withanolide C 

Relevant articles and documents

Synthetic Modifications of Withanolides with an α-Orientated Side-Chain

In view of the antitumour activity of withanolide E and 4β-hydroxywithanolide E, synthetically modified analogues were prepared.In these compounds, the α-orientation of the side-chain was retained.Its degree of bending with respect to the carbocyclic skeleton depends on the presence or absence of the 14α-OH group.Elimination of this group leads to the formation of the 14,20-oxido-bridged and Δ14-compounds.Epoxidation of the latter afforded 14α,15α-epoxides.With the exception of several 5,6-chlorohydrins, most compounds possess an epoxide ring, allylic or homoallylic with respect to the ring A enone.