816447-25-3Relevant academic research and scientific papers
Stereoselective synthesis of (±)-rocaglaol analogues
Thede, Kai,Diedrichs, Nicole,Ragot, Jacques P.
, p. 4595 - 4597 (2004)
(Chemical equation presented) An intramolecular hydroxy epoxide opening was used to access the cyclopenta[d]benzofuran ring system of the natural product rocaglaol (2). Our route allowed the stereocontrolled preparation of the rocaglaol derivative (±)-(1S*,3S*,3aR*,8bS*)-3b. The synthesis of the (±)-(3R*)-epimer of 3b was also achieved. Our strategy is well-suited for the production of analogues with variation of the western ring.
