816456-33-4

Upstream product

• 100-39-0 benzyl bromide 
• 835613-25-7 methoxymethyl 5-benzyloxy-2-methoxymethylbenzoate 
• 835613-26-8 5-benzyloxy-2-methoxymethoxy-(α,α-D2)benzyl alcohol 
• 299917-34-3 5-Benzyloxy-2-methoxymethyloxy-1-bromobenzene 
• 79352-66-2 4-(benzyloxy)-2-bromophenol 
• 16094-44-3 5-(benzyloxy)-2-hydroxybenzoic acid 
• 490-79-9 2,5-dihydroxybenzoic acid. 
• 835613-29-1 carbonic acid 4-benzyloxy-2-ethoxycarbonyloxycarbonyl-phenyl ester ethyl ester 
• 835613-28-0 4-benzyloxy-1-methoxymethoxy-2-(D₃)methylbenzene 

Relevant academic research and scientific papers

An easy two-step reduction of salicylic acids and alcohols to 2-methylphenols

Salicylic acids and alcohols can be reduced to 2-methylphenols by a simple two steps procedure. Reaction conditions were optimized carrying out a study on the solvent effect and the amount of the reducing agent. The improved procedure resulted particularly useful in the synthesis of deuterated building blocks of biological interest. Georg Thieme Verlag Stuttgart.

Approaches to the preparation of 4-benzyloxy-2-(α,α,α- D3)methylphenol, a building block for labeled δ-tocopherol, and a new synthesis of R,R,R-5-D3-α-tocopherol

Different routes are described for the synthesis of 4-benzyloxy-2-D 3-phenol, a key building block in the preparation of D 3-δ-tocopherol. Conditions for the improvement of Minami's reduction are also given, allowing a straightforward route to the title compound and a new synthesis of R,R,R-5-D3-α-tocopherol in good yields, starting from widely available R,R,R-α-tocopherol. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

First synthesis of rac-(5-2H3)-α-CEHC, a labeled analogue of a major vitamin E metabolite

Over the past few years, quantitative determination of α- and γ-CEHC, main urinary metabolites of vitamin E, has been becoming more and more important as a key parameter in assessing oxidative stress and supplementation of tocopherols. The use of deuterated analogues of these metabolites allows their accurate determination even in complex matrixes. While preparation of γ-CEHC-d2 has already been described, here we report the first synthesis of α-CEHC-d3 together with α-tocopheronolactone-d3, its oxidation product.