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1H-Imidazole, 2-(2,6-dichlorophenyl)-5-(trifluoromethyl)is a chemical compound with the molecular formula C9H5Cl2F3N2. It is a derivative of imidazole, characterized by a five-membered ring structure containing two nitrogen atoms. This specific derivative features a trifluoromethyl group and two dichlorophenyl groups attached to the imidazole ring, which may confer unique structural and chemical properties. Its potential applications in the pharmaceutical industry are currently under investigation, with a focus on its possible biological activities and therapeutic uses.

81654-11-7

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81654-11-7 Usage

Uses

Used in Pharmaceutical Industry:
1H-Imidazole, 2-(2,6-dichlorophenyl)-5-(trifluoromethyl)is used as a potential pharmaceutical compound for its possible biological activity and therapeutic effects. 1H-IMidazole, 2-(2,6-dichlorophenyl)-5-(trifluoroMethyl)-'s unique structural features, including the trifluoromethyl and dichlorophenyl groups, may contribute to its potential as a drug candidate in various medical applications.
Used in Drug Development:
In the field of drug development, 1H-Imidazole, 2-(2,6-dichlorophenyl)-5-(trifluoromethyl)is utilized for its potential to be further optimized and modified to enhance its pharmacological properties. Researchers may explore its interactions with biological targets, such as enzymes or receptors, to identify its potential therapeutic uses and improve its efficacy and safety profile.

Check Digit Verification of cas no

The CAS Registry Mumber 81654-11-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,6,5 and 4 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 81654-11:
(7*8)+(6*1)+(5*6)+(4*5)+(3*4)+(2*1)+(1*1)=127
127 % 10 = 7
So 81654-11-7 is a valid CAS Registry Number.

81654-11-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1H-Imidazole, 2-(2,6-dichlorophenyl)-5-(trifluoromethyl)-

1.2 Other means of identification

Product number -
Other names 2-(2,6-dichlorophenyl)-5-(trifluoromethyl)-1H-Imidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:81654-11-7 SDS

81654-11-7Relevant academic research and scientific papers

Imidazole-derived agonists for the neurotensin 1 receptor

Hershberger, Paul M.,Hedrick, Michael P.,Peddibhotla, Satyamaheshwar,Mangravita-Novo, Arianna,Gosalia, Palak,Li, Yujie,Gray, Wilson,Vicchiarelli, Michael,Smith, Layton H.,Chung, Thomas D.Y.,Thomas, James B.,Caron, Marc G.,Pinkerton, Anthony B.,Barak, Lawrence S.,Roth, Gregory P.

supporting information, p. 262 - 267 (2014/01/17)

A scaffold-hop program seeking full agonists of the neurotensin-1 (NTR1) receptor identified the probe molecule ML301 (1) and associated analogs, including its naphthyl analog (14) which exhibited similar properties. Compound 1 showed full agonist behavior (79-93%) with an EC50 of 2.0-4.1 μM against NTR1. Compound 1 also showed good activity in a Ca mobilization FLIPR assay (93% efficacy at 298 nM), consistent with it functioning via the G q coupled pathway, and good selectivity relative to NTR2 and GPR35. In further profiling, 1 showed low potential for promiscuity and good overall pharmacological data. This report describes the discovery, synthesis, and SAR of 1 and associated analogs. Initial in vitro pharmacologic characterization is also presented.

COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS

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Page/Page column 83-84, (2010/11/17)

Provided herein are compounds, and pharmaceutical compositions comprising such compounds, wherein the compounds are inhibitors of mPGES-1 activity. Also provided herein are methods of using such compounds and composition to treat or prevent diseases or di

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