81660-30-2

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 106-93-4 ethylene dibromide 

Downstream Products

• 1390658-53-3 1,2-bis(2-bromoacetylphenoxy)ethane 
• 1390658-56-6 1,2-bis{2-(3-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-6-yl)phenoxy}ethane 
• 1390658-65-7 1,2-bis{2-(3-phenyl-[1,2,4]triazino[3,4-b][1,3,4]thiadiazin-4(8H)-on-7-yl)phenoxy}ethane 
• 1412888-13-1 C₂₄H₂₈N₂O₄ 
• 1412888-17-5 C₃₈H₂₈Cl₂N₄O₆ 
• 77935-09-2 1,2-Bis-ethan 
• 77935-06-9 1,2-Bis(o-Hydroxyethyl-phenoxy-)ethan 

Relevant academic research and scientific papers

Macrocyclic ligand design. Structure-function relationships underlying the interaction of substituted derivatives of oxygen-nitrogen macrocycles with selected transition and post transition metal ions

The effect of methyl substitution on 15- and 17-membered macrocycles (incorporating N2O2- and N3O2-donors, respectively) on their interaction with cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and le

Bis(α-bromo ketones): Versatile precursors for novel Bis(s-triazolo[3,4-b][1,3,4]thiadiazines) and Bis(as-triazino[3,4-b][1,3,4] thiadiazines)

A synthesis of bis(α-bromo ketones) 5a-c and 6b,c was accomplished by the reaction of bis(acetophenones) 3a-c and 4b,c with N-bromosuccinimide in the presence of p-toluenesulfonic acid (p-TsOH). Treatment of 5a-c and 6b,c with each of 4-amino-3-mercapto-1

Microwave-assisted synthesis of bis(enaminoketones): Versatile precursors for novel bis(pyrazoles) via regioselective 1,3-dipolar cycloaddition with nitrileimines

Synthesis of bis(enaminones) 6a-c and 7a-c was accomplished by the reaction of bis(acetophenones) 3a-c and 4a-c with dimethylformamide-dimethylacetal, under microwave irradiation. 1,3-Dipolar cycloaddition of bis(enaminones) 6a and 7b,c with nitrileimines

Simple synthesis of a new family of 22- to 28-membered macrocycles containing two chalcone moieties

A new family of 22- to 28-membered tetrabenzo-macrocycles containing two chalcone moieties has been synthesized from 2-hydroxybenzaldehyde and 2'-hydroxyacetophenone through phenol alkylation with α,ω- dibromoalkanes followed by Claisen-Schmidt reaction u

Cyclization of 2-(2-bromoethoxy)-acetophenones and 5-(ω-haloalkoxy)- 1,5-dihydro-2H-pyrrol-2-ones - Formation of five- to eight-membered oxygen-containing heterocycles via intramolecular alkylation

Under basic conditions (lithium diisopropylamide or sodium hydride in THF) 2-(2-bromoethoxy)-acetophenones were transformed to 3,4-dihydro[1]benzoxepin- 5(2H)-ones (homochromanones) in high yields. The preparation of novel tetrahydropyrano[2,3-b]pyrrol-6(

An efficient synthetic strategy for geometrically pure symmetrical and unsymmetrical hydroxystilbenes via McMurry coupling

Intramolecular reductive deoxygenation of ethylenedioxy tethered symmetrical and unsymmetrical aromatic bis(carbonyl) ethers with the low-valent titanium (LVT) reagent (TiCl4-Zn-THF) yielded chromatographically separable E/Z-isomers of corresponding cyclic stilbenes which were further dealkylated to obtain geometrically pure hydroxystilbenes. The intramolecular McMurry coupling of the tethered bis(carbonyl) ethers with TiCl 3-Li-THF, on the other hand, directly provided both symmetrical and unsymmetrical phenanthrenes via in situ dealkoxylation of the phenol function. This is the first report of the synthesis of unsymmetrical phenanthrenes by the LVT route.

Difunctional Heterocycles: A Convenient Synthesis of Bis(4,5-dihydropyrazolyl) ethers from Their Precursors Bis(chalcones)

The new bis(4,5-dihydropyrazolyl)ethers 18-22, 26, 27 and 40-44 were prepared in 30-80 percent yields by condensation of the corresponding bis(chalcones) 13-17 and 34-37 with each of hydrazine and phenylhydrazine. Attemptes to prepare compound 20 by alkylation of 24 with 1,4-dibromobutane were unsuccessful and instead the monoalkylated derivatives 25 was obtained in 45 percent yield. Compound 24 was obtained in 63 percent yield by reacting 23 with hydrazine hydrate in refluxing acetic acid. The bis(chalcones) 13-17 and 34-37 were obtained in 65-80 percent yields by basic condensation of each of the bis(acetyl) derivatives 8-12 and the bis(aldehyde) derivatives 30-33 with benzaldehyde and acetophenone respectively. Compounds 14, 15, 35 and 36 were alternatively obtained in 32-44 percent yields by alkylation of each of the 4-cinnamoylphenol 23 and 4-benzoylvinylphenol 38 with the appropriate dibromoalkane.