81660-38-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(2,2-dimethylpropionyloxy)ethyl 3-hydroxy-alpha-methyl-L-tyrosinate is used as a potential pharmaceutical compound for its possible biological activity. Its complex structure and specific properties make it a candidate for further research and development in the field of medicine.
It is important to handle and study 1-(2,2-dimethylpropionyloxy)ethyl 3-hydroxy-alpha-methyl-L-tyrosinate with caution and use it in a controlled manner to avoid any potential risks to health and the environment. Further research is necessary to fully understand its applications and potential benefits in the pharmaceutical industry.

Upstream product

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Relevant academic research and scientific papers

Crystalline salts of L or (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters and process

Crystalline salts of (R,S)-pivaloyloxyethyl esters of (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine, processes for their preparation and pharmaceutical composition are disclosed.

Process for crystalline salts of L or (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters

Crystalline salts of (R,S)-pivaloyloxyethyl esters of (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine and processes for their preparation are disclosed.

Amino Acid Chemistry in Dipolar Aprotic Solvents: Dissociation Constants and Ambident Reactivity

The pKa's of 10 amino acids and their esters were measured spectrophotometrically in dilute Me2SO solution.The pKa's of the α-amino acids ranged from 6.3 to 7.5 and the esters from 6.4 to 8.7.The ratio of zwitterion to uncharged form of the amino acids in Me2SO ranged from 2 to 40, compared to 104-105 in aqueous solution.The primary reason for this difference is the greater solvation of the carboxylate anion in water compared to Me2SO, with solvation of the ammonium ion being similar in the two solvents.Although the zwitterion predominates in dipolar aprotic solvents, N-alkylation was competitive with O-alkylation.Reaction of the unprotected amino acids with alkyl halides gave 50-70percent yield of esters.Using alkylating agents with "harder" leaving groups increased the ester yield to 75-85percent.O-Alkylation yields were improved from 50-70percent to 85-90percent by addition of 2 equiv of LiBr to the reaction mixture.The improvement in O vs.N selectivity was attributed to a salting in of the zwitterionic form of the amino acid.