81698-81-9Relevant academic research and scientific papers
MeOTf-Mediated Annulation of Alkylnitriles and Arylalkynes Leading to Polysubstituted NH-Pyrroles
Liu, Yu,Yi, Xiangli,Luo, Xuewei,Xi, Chanjuan
, p. 11391 - 11398 (2017)
A metal-free multicomponent domino reaction for the highly regioselective synthesis of tetrasubstituted NH-pyrroles from readily available alkylnitriles, arylalkynes, and MeOTf has been developed. A variety of NH-pyrroles were obtained in moderate to good yields under mild conditions. In addition, the reactions using diarylalkynes with electron-rich aryl groups were found to afford isoquinolines.
Studies on Intramolecular Cycloaddition Reactions of Some Isoquinolinium Salts
Gisby, Graham P.,Sammes, Peter G.,Watt, Robert A.
, p. 249 - 256 (2007/10/02)
Thermally-induced intramolecular addition reactions of isoquinolinium derivatives bearing an alkenyl side-chain have been studied.Cycloadditions can occur across the isolated olefinic bond and the 1,4-positions of the isoquinolinium system to produce tetracyclic adducts.The chemistry of these adducts is compared with that of cycloadducts produced in intramolecular additions.Preparation of some of the isoquinoline derivatives involved alkylation of the parent base; 3-metylisoquinoline can be substituted either at the methyl group, upon reaction with aromatic nitriles or at C-4, using alkyl halides.
