817-11-8

Basic information

• Product Name: 3,3',3''-NITRILOTRIPROPIONIC ACID
• Synonyms: 3,3',3''-NITRILOTRIPROPIONIC ACID;NITRILOTRIPROPIONIC ACID;NTP;3,3'',3''-NITRILOTRIPROPIONIC ACID 99+%;3,3',3''-Nitrilotrispropanoic acid;3,3',3''-Nitrilotrispropionic acid;N,N-Bis(2-carboxyethyl)-β-alanine;3-[bis(2-carboxyethyl)amino]propanoic acid
• CAS NO: 817-11-8
• Molecular Formula: C₉H₁₅NO₆
• Molecular Weight: 233.22
• Mol File: 817-11-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 502.1°C at 760 mmHg
• Flash Point: 257.5°C
• Appearance: /
• Density: 1.386g/cm³
• Vapor Pressure: 1.9E-11mmHg at 25°C
• Refractive Index: 1.532
• PKA: 3.10±0.14(Predicted)
• CAS DataBase Reference: 3,3',3''-NITRILOTRIPROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3',3''-NITRILOTRIPROPIONIC ACID(817-11-8)
• EPA Substance Registry System: 3,3',3''-NITRILOTRIPROPIONIC ACID(817-11-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 817-11-8(Hazardous Substances Data)

Usage

Uses

Nitrilotripropionic Acid is a propionic NTA analog.

InChI:InChI=1/C9H15NO6/c11-7(12)1-4-10(5-2-8(13)14)6-3-9(15)16/h1-6H2,(H,11,12)(H,13,14)(H,15,16)

Upstream product

• 107-94-8 chloropropionic acid 
• 77287-34-4 formamide 
• 79-10-7 acrylic acid 
• 146743-72-8 3-[Bis-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester 
• 2664-61-1 3,3',3''-nitrilotripropanamide 

Downstream Products

• 141621-29-6 N-Benzyloxy-3-[bis-(2-benzyloxycarbamoyl-ethyl)-amino]-propionamide 
• 1224934-58-0 C₃₉H₄₈N₄O₉ 
• 1346019-43-9 C₅₄H₆₃N₇O₉ 
• 1254703-19-9 3,3',3''-nitrilotris(N-{3-[3-benzyloxy-2-methyl-4-oxopyridin-1(4H)-yl]propyl}propanamide) 

Relevant articles and documents

Synthesis and biological evaluation of 3-amino-propan-1-ol based poly(ether imine) dendrimers

A general synthetic strategy for the rapid construction of poly(ether imine) dendrons and dendrimers with a nitrogen core, originating from 3-amino-propan-1-ol, is described. A new trifunctional monomer, namely, 3-[bis-(3-hydroxypropyl)amino]propan-1-ol, was used in a divergent synthesis of dendrimers up to the third generation. This method permitted installation of, either alcohol, amine, nitrile, ester or carboxylic acid groups at the peripheries the dendrimers. Cytotoxicity studies on water-soluble carboxylic acid terminated dendrimers were conducted and these studies revealed that poly(ether imine) dendrimers were non-toxic. These results illustrate that poly(ether imine) dendrimers are useful for biological studies.

General method for the synthesis of trishydroxamic acids

Triscarboxylic acids, when treated with hydroxylamines in the presence of water-soluble carbodiimide in THF-H2O, at pH≈4.8, yield the corresponding trishydroxamic acids in good yields.