817160-11-5

Basic information

• Product Name: N-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-4-nitrobenzenesulfonamide
• Synonyms: N-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-4-nitrobenzenesulfonamide
• CAS NO: 817160-11-5
• Molecular Weight: 422.577
• Mol File: 817160-11-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-4-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-4-nitrobenzenesulfonamide(817160-11-5)
• EPA Substance Registry System: N-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-4-nitrobenzenesulfonamide(817160-11-5)

Safety Data

• Hazardous Substances Data: 817160-11-5(Hazardous Substances Data)

Upstream product

• 68847-33-6 2-[(1,1,2,2-tetramethyl-1-silapropoxy)methyl]phenylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 5344-90-1 2-Aminobenzyl alcohol 

Downstream Products

• 1579963-96-4 (2E,4E)-methyl 6-(N-(2-(hydroxymethyl)phenyl)-4-nitrophenylsulfonamido)hexa-2,4-dienoate 
• 1579963-63-5 (2E,4E)-methyl 6-(N-(2-formylphenyl)-4-nitrophenylsulfonamido)hexa-2,4-dienoate 
• 1579963-64-6 (E)-methyl 4-(1-((4-nitrophenyl)sulfonyl)-4-oxo-1,2,3,4-tetrahydroquinolin-3-yl)but-2-enoate 
• 1579963-98-6 (2E,4E)-methyl 6-(N-(2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-4-nitrophenylsulfonamido)hexa-2,4-dienoate 
• 817160-15-9 N-(2,2-dimethoxyethyl)-N-(2-hydroxymethylphenyl)-4-nitrobenzenesulfonamide 
• 817160-17-1 1-(4-nitrobenzenesulfonyl)-3-methoxy-1,2,3,5-tetrahydro-4,1-benzoxazepine 
• 817160-21-7 1-benzoyl-3-methoxy-1,2,3,5-tetrahydro-4,1-benzoxazepine 
• 817160-13-7 N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-N-(2,2-dimethoxyethyl)-4-nitrobenzenesulfonamide 

Relevant articles and documents

1H and 13C NMR spectral data of p-nitrobenzenesulfonamides and dansylsulfonamides derived from N-alkylated o-(Purinemethyl)anilines

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Synthesis of tetrahydrobenzoxazepine acetals with electron-withdrawing groups on the nitrogen atom. Novel scaffolds endowed with anticancer activity against breast cancer cells

Synthetic approaches that have led to (RS)-3-methoxy-N-substituded-1,2,3,5- tetrahydro-4,1-benzoxazepines with different electron-withdrawing groups, and (RS)-2-methoxy-N-trifluoroacetyl-2,3,4,5-tetrahydro-1,4-benzoxazepine are described. These novel synthons that were designed to be used as scaffolds for the preparation of new O,N-acetals as anticancer agents, unexpectedly proved to show antiproliferative activity against the MCF-7 breast cancer cell line. It has been found that substituents on the nitrogen atom have an influence on biological activity. In particular, the presence of a trifluoroacetyl moiety on the nitrogen atom leads to amides displaying interesting in vitro antitumour activities. Graphical Abstract.