817166-94-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 817166-95-3 [(1S)-1-[(4R)-4-benzyl-5-oxotetrahydrofuran-(2R)-2-yl]-4-(tert-butyldimethylsilanyloxy)butyl]carbamic acid tert-butyl ester 
• 817166-99-7 (4R,5S)-5-tert-butoxycarbonylamino-8-(tert-butyldimethylsilanyloxy)-4-hydroxyoctanoic acid methyl ester 
• 471282-37-8 [3-tert-butoxycarbonylamino-6-(tert-butyldimethylsilanyloxy)-2-oxohexyl]phosphonic acid dimethyl ester 
• 817166-98-6 (2S)-2-tert-butoxycarbonylamino-5-(tert-butyldimethyl-silanyloxy)-pentanoic acid benzyl ester 
• 817166-97-5 5-tert-butoxycarbonylamino-8-(tert-butyldimethylsilanyloxy)-4-oxooctanoic acid methyl ester 
• 817166-96-4 [4-(tert-butyldimethylsilanyloxy)-(1S)-1-(5-oxotetrahydrofuran-(2R)-2-yl)butyl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of a Gln-Phe hydroxy-ethylene dipeptide isostere

(Chemical Equation Presented) The protected Gln-Phe hydroxyethylene dipeptide isostere 1 was synthesized as a precursor for preparation of potential inhibitors of Botulinum neurotoxin B metalloprotease. The method allows for the synthesis of additional hydroxyethylene dipeptide isosteres such as 2 with functionalized P1 side chains. The isosteres prepared were coupled with a dipeptide to produce protected pseudotetrapeptide derivatives.