81720-94-7

Basic information

• Product Name: (4-amino-2-chlorophenyl)(4-chlorophenyl)acetonitrile
• Synonyms: (4-amino-2-chlorophenyl)(4-chlorophenyl)acetonitrile;4-Amino-2-chloro-α-(4-chlorophenyl)benzeneacetonitrile;Einecs 279-801-4
• CAS NO: 81720-94-7
• Molecular Formula: C₁₄H₁₀Cl₂N₂
• Molecular Weight: 277.1486
• EINECS: 279-801-4
• Mol File: 81720-94-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 445°Cat760mmHg
• Flash Point: 222.9°C
• Appearance: /
• Density: 1.347g/cm³
• Vapor Pressure: 4.1E-08mmHg at 25°C
• Refractive Index: 1.64
• CAS DataBase Reference: (4-amino-2-chlorophenyl)(4-chlorophenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (4-amino-2-chlorophenyl)(4-chlorophenyl)acetonitrile(81720-94-7)
• EPA Substance Registry System: (4-amino-2-chlorophenyl)(4-chlorophenyl)acetonitrile(81720-94-7)

Safety Data

• Hazardous Substances Data: 81720-94-7(Hazardous Substances Data)

Usage

General Description

(4-amino-2-chlorophenyl)(4-chlorophenyl)acetonitrile is a chemical compound with the molecular formula C14H9Cl2N. It is a nitrile compound that contains two phenyl rings, each substituted with chlorine atoms and a cyano group attached to the central carbon atom. (4-amino-2-chlorophenyl)(4-chlorophenyl)acetonitrile is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological and pharmacological activities, including its antiproliferative and antitumor properties. Additionally, it may serve as a useful building block for the development of new chemical entities with diverse applications in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C14H10Cl2N2/c15-10-3-1-9(2-4-10)13(8-17)12-6-5-11(18)7-14(12)16/h1-7,13H,18H2

Upstream product

• 108-88-3 toluene 

Relevant articles and documents

4,5-dihydro-isoxazole derivatives and their pharmaceutical use

The present invention is concerned with the compounds of formula wherein m, n and p are each independently 0 or 1 and q is 0, 1, 2, 3, 4 or 5; —A1═A2—A3═A4— is a pyridinylidene, pyridazinylidene, pyrimidinylidene, pyrazinylidene or phenylidene; B represents an amide, ketone or oxadiazole; D represents Ar or Het; Q represents a covalent direct bond or a ketone, —N—, —O—, —CR5R6—, amide ethenyl, imine, sulfonyl, sulfinyl, 3-oxobutenyl, pyrazole, isoxazole or thiazole; L represents Ar or Het; R1represents hydrogen, halo, hydroxy, C(2-6)alkenyl, C(2-6)alkynyl, C(3-6)cycloalkyl, C(3-6)cycloalkenyl, cyano, guanidine, nitro, NR17R18, an optionally substituted C(1-6)alkyl or C(1-6)alkyloxy; R2and R3each independently represent hydrogen, halo, C(1-6)alkyloxy or an optionally substituted C(1-6)alkyl; R5and R6each independently represent hydrogen, hydroxy, halo, an optionally substituted C(1-6)alkyl, C(2-6)alkenyl, C(2-6)alkynyl, C(3-6)cycloalkyl, C(3-6)cycloalkenyl, C(1-6)alkyloxy, cyano, (C═O)R25, (C═O)OR16, (SO2)R16, aminocarbonyloxy, aminoC(1-6)alkyl, NR17R18, N3, Ar or Het; or R5and R6together with the carbon atom to which they are attached, form an Ar or Het; Ar represents an optionally substituted C(6-14)aryl; Het represents an optionally substituted C(1-14)heterocycle; or a N-oxide, pharmaceutically acceptable addition salt, quaternary amine or stereochemically isomeric form thereof; the processes for their preparation and compositions comprising them. It further relates to their use as a medicine.