81721-80-4

Upstream product

• 1384384-84-2 C₁₇H₁₇NO₃ 
• 1384384-86-4 C₂₃H₁₇NO₂ 
• 1384384-78-4 N-benzyl-N-[1-(2-hydroxymethylphenyl)vinyl]-2-methoxybenzamide 
• 1018679-04-3 C₂₃H₁₇NO₂ 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 73178-23-1 N-benzyl-2-iodobenzamide 
• 579-75-9 2-Methoxybenzoic acid 
• 183198-63-2 N-benzyl-2-methoxylbenzamide 

Relevant academic research and scientific papers

Preparation method of indenoisoquinoline derivative

The invention relates to a preparation method of an indenoisoquinoline derivative as shown in formula (I). The preparation method includes the steps of (A), providing a first reactant as shown in formula (II) and a second reactant as shown in formula (III

METHOD FOR PREPARING INDENOISOQUINOLINE DERIVATIVES

A method for preparing indenoisoquinoline derivatives represented by the following formula (I) is disclosed, which comprises the following steps: (A) providing a first reactant represented by the following formula (II) and a second reactant represented by the following formula (III): wherein, R1, R3, A, X, Y, Z, m and n are defined in the specification; and (B) reacting the first reactant represented by the formula (II) and the second reactant represented by the formula (III) in a solvent and selectively adding R2NH2 therein, to obtain the indenoisoquinoline derivatives represented by the formula (I).

Synthesis of Biologically Active Indenoisoquinoline Derivatives via a One-Pot Copper(II)-Catalyzed Tandem Reaction

A concise route for the synthesis of indenoisoquinoline derivatives from 2-iodobenzamide and 1,3-indanedione derivatives in the presence of copper(II) chloride and cesium carbonate in acetonitrile solvent is reported. A wide variety of 2-iodobenzamide derivatives and indandiones could be used to synthesize indenoisoquinoline derivatives and other fused indenoisoquinoline in moderate to good yields. This methodology was adapted for the one-step synthesis of a series of clinically active topoisomerase I inhibitors such as NSC 314622, LMP-400, LMP-776.

Photochemically induced synthesis of the topoisomerase i inhibitors indeno [1,2-c]isoquinoline-5,11-diones

A convenient synthesis of indeno[1,2-c]isoquinoline-5,11-diones has been achieved using combinational photochemical and carbocationic cyclization tactics. The synthetic route involved first the construction of adequately functionalized N-styryl benzamides via Suzuki-Miyaura cross-coupling reaction with enol phosphate combined with a six - electron photocyclization process. The assembling of the title compounds was readily ensured through sequential carbocationic annulation reaction and ultimate oxidation of a latent hydroxy functionality. Georg Thieme Verlag Stuttgart · New York.