81732-54-9Relevant academic research and scientific papers
Preparation method of terbutaline derivatives
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Paragraph 0046-0048; 0053-0055, (2020/08/02)
The invention discloses a preparation method of terbutaline derivatives, belongs to the field of compound preparation, and provides a synthesis method of a novel drug molecule acotiamide derivative, which is reasonable in process design, high in yield and convenient and controllable in operation process. The invention provides a preparation method of three terbutaline derivatives. The preparationmethod provided by the invention has the advantages of reasonable process design, strong operability, mild reaction conditions and high yield, and can realize industrial production. The series of terbutaline derivatives prepared by the method provide important basis for scientific evaluation of quality, safety and efficiency of the series of terbutaline derivatives, and have important applicationvalue.
A Practical Method for the Preparation of 2-Arylbenzofurans and the Synthesis of Moracin A and B
Vu, Binh,Mezey-Vandor, Gabriella,Nogradi, Mihaly
, p. 734 - 741 (2007/10/02)
Oxidative rearrangement of 2-benzyloxychalcones 2 with Tl(NO3)3 in methanol to 1,2-diaryl-3,3-dimethoxy-1-propanones 3, alkaline degradation to aryl 2-benzyloxybenzyl ketones 4, debenzylation, and ring closure gave 2-arylbenzofurans 1.In this way moracin A and B (1a, b), further 2-(2,4-dihydroxyphenyl)-5,6-dimethoxybenzofuran (1c) were synthesized.The latter was not identical with a substance isolated from Myroxylon balsamum for which structure 1c was claimed.
