81733-79-1

Basic information

• Product Name: (D-ALA2)-LEUCINE ENKEPHALIN-ARG
• Synonyms: (D-ALA2)-LEUCINE ENKEPHALIN-ARG;ala(2)-arg(6)-enkephalin-le;cyl)-;inine;l-arginine,n(sup2)-(n-(n-(n-(l-tyrosyl-d-alanyl)glycyl)-l-phenylalanyl)-l-leu;n(sup2)-(n-(n-(n-(l-tyrosyl-d-alanyl)glycyl)-l-phenylalanyl)-l-leucyl)-l-arg;tyrosyl-d-alanyl-glycyl-phenylalanyl-leucyl-arginine;enkephalin-Leu, Ala(2)-Arg(6)-
• CAS NO: 81733-79-1
• Molecular Formula: C₃₅H₅₁N₉O₈
• Molecular Weight: 725.83494
• Mol File: 81733-79-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.36g/cm³
• Refractive Index: 1.629
• PKA: 3.34±0.10(Predicted)
• CAS DataBase Reference: (D-ALA2)-LEUCINE ENKEPHALIN-ARG(CAS DataBase Reference)
• NIST Chemistry Reference: (D-ALA2)-LEUCINE ENKEPHALIN-ARG(81733-79-1)
• EPA Substance Registry System: (D-ALA2)-LEUCINE ENKEPHALIN-ARG(81733-79-1)

Safety Data

• Hazardous Substances Data: 81733-79-1(Hazardous Substances Data)

Usage

General Description

(D-ALA2)-LEUCINE ENKEPHALIN-ARG, also known as DADLE, is a synthetic enkephalin analogue and an opioid peptide with potent analgesic and anti-inflammatory effects. It is a selective agonist for the delta opioid receptor and has been used in various research studies to investigate the role of delta opioid receptors in pain modulation, addiction, and mood disorders. DADLE is commonly used in the laboratory to study the mechanisms of opioid action, and its synthetic nature allows for precise control and manipulation in experimental settings. Studies have shown that DADLE has potential therapeutic applications for the treatment of chronic pain and neuroinflammatory conditions.

InChI:InChI=1/C35H51N9O8/c1-3-4-11-26(32(49)44-27(34(51)52)12-8-17-39-35(37)38)43-33(50)28(19-22-9-6-5-7-10-22)42-29(46)20-40-30(47)21(2)41-31(48)25(36)18-23-13-15-24(45)16-14-23/h5-7,9-10,13-16,21,25-28,45H,3-4,8,11-12,17-20,36H2,1-2H3,(H,40,47)(H,41,48)(H,42,46)(H,43,50)(H,44,49)(H,51,52)(H4,37,38,39)/t21-,25+,26+,27+,28+/m1/s1

Upstream product

• 74-79-3 L-arginine 
• 3397-35-1 Z-L-leucine hydroxysuccinimide ester 
• 126399-13-1 Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycine p-nitrophenyl ester 
• 70663-49-9 H-Ala-Gly(OBzl) 
• 64410-44-2 N-(tert-butoxycarbonyl)-D-alanylglycine benzyl ester 
• 26607-15-8 LR 

Relevant articles and documents

Antiviral Immunotropic Agent for the Treatment of Acute Respiratory Viral Infections

The proposed methods of treatment pertain to medicine, in particular pharmacology, and concerns the application of a nasal medicinal composition containing hexapeptide tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine or its pharmaceutically acceptable