81743-92-2Relevant academic research and scientific papers
Water-dependent synthesis of biologically active diaryl diselenides
Pacu?a, Agata J.,Obieziurska, Magdalena,?cianowski, Jacek,Kaczor, Katarzyna B.,Antosiewicz, J?drzej
, p. 153 - 164 (2018/07/05)
A new one-step method for the synthesis of diaryl diselenides has been developed. The reaction of o-iodobenzamides with dilithium diselenide can be controlled by the presence of water providing a simple and efficient protocol to obtain benzisoselenazolones or diaryl diselenides. A series of N-Aryl ebselen derivatives and the corresponding diselenides was obtained. All synthesized compounds were tested in vitro as antioxidants and cytotoxic agents. N-(2,3,4-Trimethoxyphenyl)benzisoselenazol-3(2H)-one was the best in vitro antioxidant and the corresponding diselenide the most potent cytotoxic agent against prostate cancer cell line DU145, being inactive towards healthy prostate cell line PNT1A. Formula parented.
Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones
Pacula, Agata J.,cianowski, Jacek,Aleksandrzak, Krzysztof B.
, p. 49959 - 49962 (2014/12/10)
A new, general one step synthesis of N-substituted benzisoselenazol-3(2H)-ones based on the reaction of o-iodobenzamides with lithium diselenide, is described. A series of alkyl and aryl derivatives was obtained in high yields (up to 98%). Their GPx-like antioxidant activity, tested by NMR, showed a significantly higher activity than ebselen.
