817575-39-6Relevant academic research and scientific papers
Design and synthesis of novel type VI-like β-turn mimetics. Diversity at the i+1 and the i+2 position
De Borggraeve, Wim M.,Verbist, Bie M.P.,Rombouts, Frederik J.R.,Pawar, Vijaykumar G.,Smets, Wim J.,Kamoune, Laila,Alen, Jo,Van Der Eycken, Erik V.,Compernolle, Frans,Hoornaert, Georges J.
, p. 11597 - 11612 (2007/10/03)
In this paper, a synthetic approach for functionalised 5-aminopiperidinone- 2-carboxylate (APC) systems as non-pro cis-peptide bond containing external β-turn mimics is presented. The scope and limitations of the synthetic method are discussed and the pot
Acid catalysed methanolysis of 2,5-diazabicyclo[2.2.2]octane-3,6-diones: Scope and limitations
Verbist, Bie M. P.,Smets, Wim J.,De Borggraeve, Wim M.,Compernolle, Frans,Hoornaert, Georges J.
, p. 4371 - 4374 (2007/10/03)
The selective methanolysis of 2,5-diazabicyclo[2.2.2]octane-3,6-dione systems is a key step in a synthetic procedure leading to 4-amino-6-oxo-2- piperidinecarboxylate systems. This reaction seems to be primarily governed by steric hindrance caused by the substituents at the 1- and 4-bridgehead positions of the dione. In absence of bulky substituents the methanolysis is directed by the secondary or tertiary nature of the two lactam moieties.
