81765-90-4

Upstream product

• 81765-89-1 3-cyano-5,6-diphenyl-1,2,4-triazine 
• 105-56-6 ethyl 2-cyanoacetate 
• 81765-86-8 3-methanesulphonyl-5,6-diphenyl-[1,2,4]triazine 
• 28735-33-3 5,6-diphenyl-3-methylthio-1,2,4-triazine 
• 34177-11-2 3-chloro-5,6-diphenyl-1,2,4-triazine 
• 81765-85-7 5,6-diphenyl-3-(p-toluenesulfonyl)-as-triazine 

Relevant academic research and scientific papers

Studies on Pyrimidine Derivatives. XXIV. Synthesis of 3-Substituted 1,2,4-Triazines by Nucleophilic Substitution

The potassium permanganate oxidation of 3-methylthio-5,6-diphenyl-as-triazine in the presence of a phase-transfer catalyst afforded 3-methylsulfonyl-5,6-diphenyl-as-triazine.The 3-sulfonyl-as-triazine readily reacted not only with active methylene compounds but also with methyl or methylene ketones under basic conditions, and 5,6-diphenyl-as-triazines containing a functionalized carbon substituent at the 3-position were obtained.Similarly, 2-substituted 4,6-dimethylpyrimidines were synthesized by the nucleophilic substitution of 4,6-dimethyl-2-phenylsulfonylpyrimidine with various ketones.