28735-33-3Relevant academic research and scientific papers
In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells
Yurtta, Leyla,Demirayak, eref,Ilgin, Sinem,Atli, ?zlem
, p. 6313 - 6323 (2014)
A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis(4-subtituted phenyl)-1,2,4-triazin-3-yl)piperazin-1-yl]-2-[4-(3-substituted phenyl)pipera
Synthesis and screening of (E)-3-(2-benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine analogs as novel dual inhibitors of α-amylase and α-glucosidase
Alhowail, Ahmad,Ali, Muhammad,Chigurupati, Sridevi,Khan, Khalid Mohammed,Perveen, Shahnaz,Salar, Uzma,Shamim, Shahbaz,Taha, Muhammad,Ullah, Nisar,Ur Rehman, Ashfaq,Wadood, Abdul
, (2020/06/22)
(E)-3-(2-Benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazines analogs 1–27 were synthesized by multi-step reaction scheme and subjected to in vitro inhibitory screening against α-amylase and α-glucosidase enzymes. Out of these twenty-seven synthetic analog
Multi-target inhibitors against Alzheimer disease derived from 3-hydrazinyl 1,2,4-triazine scaffold containing pendant phenoxy methyl-1,2,3-triazole: Design, synthesis and biological evaluation
Yazdani, Mahnaz,Edraki, Najmeh,Badri, Rashid,Khoshneviszadeh, Mehdi,Iraji, Aida,Firuzi, Omidreza
, p. 363 - 371 (2018/12/11)
Alzheimer's disease (AD) is a complex neurological disorder with diverse underlying pathological processes. Several lines of evidence suggest that BACE1 is a key enzyme in the pathogenesis of AD and its inhibition is of particular importance in AD treatme
Synthesis, anti-proliferative evaluation, and molecular docking studies of 3-(Alkylthio)-5,6-diaryl-1,2,4-triazines as tubulin polymerization inhibitors
Saravani, Farhad,Moghadam, Ebrahim Saeedian,Salehabadi, Hafezeh,Ostad, Seyednasser,Hamedani, Morteza Pirali,Amanlou, Massoud,Faramarzi, Mohammad Ali,Amini, Mohsen
, p. 1194 - 1201 (2019/11/22)
Background: The role of microtubules in cell division and signaling, intercellular transport, and mitosis has been well known. Hence, they have been targeted for several anti-cancer drugs. Methods: A series of 3-(alkylthio)-5,6-diphenyl-1,2,4-triazines were prepared and evaluated for their cytotoxic activities in vitro against three human cancer cell lines; human colon carcinoma cells HT-29, human breast adenocarcinoma cell line MCF-7, human Caucasian gastric adenocarcinoma cell line AGS as well as fibroblast cell line NIH-3T3 by MTT assay. Docking simulation was performed to insert these compounds into the crystal structure of tubulin at the colchicine binding site to determine a probable binding model. Compound 5d as the most active compound was selected for studying of microtubule disruption. Results: Compound 5d showed potent cytotoxic activity against all cell lines. The molecular modeling study revealed that some derivatives of triazine strongly bind to colchicine binding site. The tubulin polymerization assay kit showed that the cytotoxic activity of 5d may be related to inhibition of tubulin polymerization. Conclusion: The cytotoxicity and molecular modeling study of the synthesized compounds with their inhibition activity in tubulin polymerization demonstrate the potential of triazine derivatives for development of new anti-cancer agents.
Design, green synthesis and pharmacological evaluation of novel 5,6-diaryl-1,2,4-triazines bearing 3-morpholinoethylamine moiety as potential antithrombotic agents*
Tamboli, Riyaj S.,Giridhar, Rajani,Gandhi, Hardik P.,Kanhed, Ashish M.,Mande, Hemant M.,Yadav, Mange Ram
, p. 704 - 713 (2016/07/07)
The aim of this research work was to investigate a series of novel 5,6-diaryl-1,2,4-triazines (3a–3q) containing 3-morpholinoethylamine side chain, and to address their antiplatelet activity by in vitro, ex vivo and in vivo methods. All compounds were syn
Room-temperature ionic liquid-DMSO promoted and improved one-pot synthesis of 5,6-diaryl-1,2,4-triazines
Tamboli, Riyaj S.,Giridhar, Rajani,Mande, Hemant M.,Shah, Shailesh R.,Yadav, Mange Ram
supporting information, p. 2192 - 2204 (2014/07/07)
An improved and rapid one-pot synthesis of 5,6-diarylsubstituted-1,2,4- triazines in a mixture of room-temperature ionic liquid 1,3-dibutylimidazolium bromide [Bbim]+Br- and dimethylsulfoxide (DMSO) is described without the need for
NITROGEN HETEROCYCLE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN HUMAN THERAPEUTICS
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Paragraph 0229; 0230, (2013/03/26)
The present invention relates to compounds having general formula I characterised in that wherein in particular: R1 represents one or a plurality of groups such as: trifluoromethyl, halogen such as F, Cl, Br, methyl, nitro. R represents nitroge
Synthesis and antitumor activity of new 1,2,4-triazine and [1,2,4]triazolo[4,3-b][1,2,4]triazine derivatives and their thioglycoside and acyclic C-nucleoside analogs
El-Sayed, Wael A.,Nassar, Ibrahim F.,Abdel-Rahman, Adel A.-H.
experimental part, p. 135 - 143 (2011/03/21)
New 1,2,4-triazine and their derived 1,2,4-triazolo[3,4-b][1,2,4]triazine derivatives were synthesized starting from 5,6-diphenyl-1,2,4-triazine-3-thiol. Furthermore, the corresponding 1,2,4-triazolo[3,4-b][1,2,4]-triazine thioglycosides and acyclic C-nuc
Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents
Irannejad, Hamid,Amini, Mohsen,Khodagholi, Fariba,Ansari, Niloufar,Tusi, Solaleh Khoramian,Sharifzadeh, Mohammad,Shafiee, Abbas
experimental part, p. 4224 - 4230 (2010/09/12)
The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on differentiated rat pheochromocytoma (PC12) cell line was examined and a consistent protection from H2O2-induced cell death, associated with a marked reduction in caspase-3 activation, was observed. Moreover, activation of NF-κB, a known regulator of a host of genes that involves in specific stress and inflammatory responses by H2O2, was greatly impaired by triazine pretreatment in differentiated PC12 cells. Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases.
HETEROAROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR AGONIST BIOLOGICAL ACTIVITY
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Page/Page column 28, (2008/06/13)
A novel compound having agonist activity at the S1P3 receptor which is represented by the formula I wherein X is selected from the group consisting of CR3, N and NO;Y is selected from the group consisting of CR3, N and NO;Z is selected from the group consisting of CR3, N and NO; and at least one of X, Y and Z is N or NO; V is O or NOR4 R1 is an aryl group;R2 is an aryl group;R3 is selected from the group consisting of H and alkyl; and 2 of said R3 groups may together form a cyclic alkyl ring having from 3 to 6 carbon atoms; R4 is selected from the group consisting of H and alkyl;a is 0 or an integer of from 1 to 6;b is 0 or 1;c is 0 or 1;f is 0 or an integer of 1 or 2;x is 0 or 1;y is 0 or an integer of from 1 to 3; andz is 0 or an integer of from 1 to 3.
