81765-91-5

Upstream product

• 81765-86-8 3-methanesulphonyl-5,6-diphenyl-[1,2,4]triazine 
• 141-97-9 ethyl acetoacetate 
• 81765-85-7 5,6-diphenyl-3-(p-toluenesulfonyl)-as-triazine 
• 28735-33-3 5,6-diphenyl-3-methylthio-1,2,4-triazine 
• 34177-11-2 3-chloro-5,6-diphenyl-1,2,4-triazine 

Relevant academic research and scientific papers

HETEROAROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR AGONIST BIOLOGICAL ACTIVITY

A novel compound having agonist activity at the S1P3 receptor which is represented by the formula I wherein X is selected from the group consisting of CR3, N and NO;Y is selected from the group consisting of CR3, N and NO;Z is selected from the group consisting of CR3, N and NO; and at least one of X, Y and Z is N or NO; V is O or NOR4 R1 is an aryl group;R2 is an aryl group;R3 is selected from the group consisting of H and alkyl; and 2 of said R3 groups may together form a cyclic alkyl ring having from 3 to 6 carbon atoms; R4 is selected from the group consisting of H and alkyl;a is 0 or an integer of from 1 to 6;b is 0 or 1;c is 0 or 1;f is 0 or an integer of 1 or 2;x is 0 or 1;y is 0 or an integer of from 1 to 3; andz is 0 or an integer of from 1 to 3.

Studies on Pyrimidine Derivatives. XXIV. Synthesis of 3-Substituted 1,2,4-Triazines by Nucleophilic Substitution

The potassium permanganate oxidation of 3-methylthio-5,6-diphenyl-as-triazine in the presence of a phase-transfer catalyst afforded 3-methylsulfonyl-5,6-diphenyl-as-triazine.The 3-sulfonyl-as-triazine readily reacted not only with active methylene compounds but also with methyl or methylene ketones under basic conditions, and 5,6-diphenyl-as-triazines containing a functionalized carbon substituent at the 3-position were obtained.Similarly, 2-substituted 4,6-dimethylpyrimidines were synthesized by the nucleophilic substitution of 4,6-dimethyl-2-phenylsulfonylpyrimidine with various ketones.