81778-06-5Relevant articles and documents
Preparation method of clomazone
-
Paragraph 0003-0004, (2021/06/26)
The invention relates to a preparation method of clomazone. The method comprises: by taking hydroxylamine hydrochloride as a raw material, dropwise adding chloro pivaloyl chloride under the action of a self-made ether catalyst to obtain an intermediate 3-chloro-N-hydroxyl-2, 2-dimethyl propionamide with high yield, then cyclizing to prepare 4, 4-dimethyl-3-isoxazolone, and carrying out benzylation under pioneered caustic soda flake catalysis without separation to directly prepare 2-(2-chlorphenyl) methyl-4, 4-dimethyl-3-isoxazolone. Compared with existing literature methods, the method of the invention has the advantages that the self-made ether catalyst is innovatively used, so that the yield in the first step is remarkably improved, and the content and optical purity of the product are high; in the final benzylation reaction, caustic soda flakes are used to improve the yield, and water is used as a solvent in the whole reaction process, so that the cost is low, the recovery and post-treatment are simple, the reaction is mild, and the intermediate control is simple; and the preparation method provided by the invention has the advantages of easily available reaction raw materials, mild reaction, high yield, simple separation and purification, low cost and environment-friendly preparation process.
Preparation method of clomazone
-
Paragraph 0016; 0019; 0022; 0025, (2017/08/29)
The invention relates to a preparation method of clomazone, wherein an intermediate, 4,4-dimethylisoxazole-3-one, is synthesized by dropwise adding chloro-pivaloyl chloride to a raw material, hydroxylamine hydrochloride, under the effects of a self-made ether catalyst; and then the intermediate is condensed with o-chlorobenzyl chloride under the effects of a caustic soda flake catalyst to synthesize a raw drug of the clomazone. The preparation method uses easy-to-obtained raw materials and mild reactions, is high in yield and is simple in separation and purification, has low cost, is environment-friendly, and has great industrial application prospect.
A new method for preparing N-acyloxaziridines via tandem O, N-addition of hydroxamic acids to methyl propiolate.
Zong, Kyukwan,Shin, Seung Il,Ryu, Eung Kul
, p. 6227 - 6228 (2007/10/03)
N-Acyloxaziridines were prepared from a tandem O, N-addition of hydroxamic acids to metyl propiolate in the presence of 4-methyl morpholine as a catalyst in good to excellent yields.