81793-93-3Relevant academic research and scientific papers
THE PROTECTION OF URACIL AND GUANINE RESIDUES IN OLIGONUCLEOTIDE SYNTHESIS
Jones, Simon S.,Reese, Colin B.,Sibanda, Samson,Ubasawa, Aiko
, p. 4755 - 4758 (1981)
The protection of uracil and 2-N-acyl guanine residues with 4-O-phenyl and 6-O-(2-nitrophenyl) groups as in 7a (or 7b) and 9, respectively, is described.These O-aril protecting groups, which appear to withstand the usual conditions of oligonucleotide synthesis, may readily be removed by treatment with 2-nitrobenzaldoximate ions.
