THE PROTECTION OF URACIL AND GUANINE RESIDUES IN OLIGONUCLEOTIDE SYNTHESIS

DOI: 10.1016/S0040-4039(01)83032-X

Source and publish data:

Tetrahedron Letters p. 4755 - 4758 (1981)

Update date:2022-08-04

Topics:

Authors:

Jones, Simon S.

Reese, Colin B.

Sibanda, Samson

Ubasawa, Aiko

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Article abstract of DOI:10.1016/S0040-4039(01)83032-X

The protection of uracil and 2-N-acyl guanine residues with 4-O-phenyl and 6-O-(2-nitrophenyl) groups as in 7a (or 7b) and 9, respectively, is described.These O-aril protecting groups, which appear to withstand the usual conditions of oligonucleotide synthesis, may readily be removed by treatment with 2-nitrobenzaldoximate ions.

Full text of DOI:10.1016/S0040-4039(01)83032-X

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