818-26-8

Upstream product

• 111-71-7 heptanal 
• 13038-21-6 non-8-en-1-ol 
• 14065-32-8 methyl 10-chloro-10-oxodecanoate 
• 111-25-1 1-bromo-hexane 
• 689-69-0 methyl 10-oxohexadecanoate 
• 111-20-6 1,10-decanedioic acid 
• 111-19-3 sebacoyl chloride 
• 3761-92-0 n-hexylmagnesium bromide 
• 60-29-7 diethyl ether 

Downstream Products

• 57-11-4 stearic acid 
• 3422-30-8 10-hydroxy-hexadecanoic acid 

Relevant academic research and scientific papers

Global Mapping of Protein–Lipid Interactions by Using Modified Choline-Containing Phospholipids Metabolically Synthesized in Live Cells

The protein–lipid interaction is an essential metabolic process that mediates cellular signaling and functions. Existing strategies for large-scale mapping studies of the protein–lipid interaction fall short in their incompatibility with metabolic incorporation or inability to remove unwanted interferences from lipidated proteins. By incorporating an alkyne-containing choline head group and a diazirine-modified fatty acid simultaneously into choline-containing phospholipids synthesized from live mammalian cells, protein–phospholipid interactions have been successfully imaged in live cells. Subsequent in situ profiling of the modified Cho phospholipid-crosslinked proteins followed by quantitative proteomics allowed identification of several hundred putative phospholipid-interacting proteins, some of which were further validated.

Saturated Oxo Fatty Acids (SOFAs): A Previously Unrecognized Class of Endogenous Bioactive Lipids Exhibiting a Cell Growth Inhibitory Activity

The discovery of novel bioactive lipids that promote human health is of great importance. Combining suspect and targeted lipidomic liquid chromatography-high-resolution mass spectrometry (LC-HRMS) approaches, a previously unrecognized class of oxidized fatty acids, the saturated oxo fatty acids (SOFAs), which carry the oxo functionality at various positions of the long chain, was identified in human plasma. A library of SOFAs was constructed, applying a simple green photochemical hydroacylation reaction as the key synthetic step. The synthesized SOFAs were studied for their ability to inhibit in vitro the cell growth of three human cancer cell lines. Four oxostearic acids (OSAs) were identified to inhibit the cell growth of human lung carcinoma A549 cells. 6OSA and 7OSA exhibited the highest cell growth inhibitory potency, suppressing the expression of both STAT3 and c-myc, which are critical regulators of cell growth and proliferation. Thus, naturally occurring SOFAs may play a role in the protection of human health.