81823-03-2

Upstream product

• 81823-01-0 3,4,6-tri-O-benzyl-1,2-di-O-p-nitrobenzoyl-D-glucopyranose 
• 81823-02-1 3,4,6-tri-O-benzyl-2-O-p-nitrobenzoyl-α-D-glucopyranosyl chloride 
• 20672-66-6 3,4,6-tri-O-benzyl-D-glucopyranose 
• 70274-98-5 2-<4-(p-toluenesulfonamido)-phenyl>ethanol 

Downstream Products

• 26887-94-5 β-D-Glc p-(1->2)-β-D-Glc 
• 81823-09-8 4-Nitro-benzoic acid (2S,3R,4S,5R,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-((2R,3R,4S,5R,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-{2-[4-(toluene-4-sulfonylamino)-phenyl]-ethoxy}-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-3-yl ester 
• 81823-11-2 N-(4-{2-[(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-3-hydroxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-ethyl}-phenyl)-4-methyl-benzenesulfonamide 
• 81823-04-3 2-<4-(p-toluenesulfonamido)phenyl>ethyl 3,4,6-tri-O-benzyl-β-D-glucopyranoside 

Relevant academic research and scientific papers

The synthesis of alpha and beta-(1 less than 2) and-(1 less than 3)-linked glucopyranose disaccharides and their protein conjugates.

2,3,4-Tri-O-benzyl-6-O-(N-phenylcarbamoyl)-1-O-tosyl-D-glucopyranose and 3,4,6-tri-O-benzyl-2-O-p-nitrobenzoyl-1-O-tosyl-D-glucopyranose were allowed to react with partially blocked 2-[4-p-toluenesulfonamido) phenyl]ethyl alpha- and beta-D-glucopyranosides. Disaccharides having the structure alpha-D-Glcp-(1 goes to 2)-alpha-D-Glcp, alpha-D-Glcp-(1 goes to 3)-alpha-D-Glcp, beta-D-Glcp-(1 goes to 2)-beta-D-Glcp, and beta-D-Glcp-(1 goes to 3)-alpha-D-Glcp were synthesized. The oligosaccharides were debenzylated with sodium in liquid ammonia to give disaccharides having a free primary aromatic amino group, which were converted into isothiocyanate derivatives and then coupled to various proteins to give the corresponding conjugates.