81835-71-4Relevant academic research and scientific papers
A Novel Synthesis of 2-Aryl-4-Piperidones By Mannich Cyclization of Iminoketals (1)
Bosch, Joan,Rubiralta, Mario,Moral, Montserrat,Valls, Maria
, p. 595 - 606 (2007/10/02)
2-Aryl-4-piperidones have been synthesized by condensation between an aromatic aldehyde and a β-aminoketone ethylene ketal, and further cyclization of the resulting iminoketal with dry hydrogen chloride or anhydrous p-toluenesulfonic acid.Alternatively, r
MANNICH CYCLIZATION INVOLVING THE α-POSITION OF KETALS: SYNTHESIS OF 2-ARYL-4-PIPERIDONES AND 2-ARYL-3-ACYLPYRROLIDINES
Bosch, Joan,Rubiralta, Mario,Moral, Montserrat
, p. 473 - 476 (2007/10/02)
A new method for the preparation of 2-aryl-4-piperidones and 2-aryl-3-acylpyrrolidines based on the acid-induced intramolecular cyclization between an iminium salt and the α-position of a ketal group is reported.
