81847-06-5Relevant academic research and scientific papers
Potential Bile Acid Metabolites; 12. Synthesis of Stereoisomeric 3,7,12-Trihydroxy-5α-cholanic Acids and Related Compounds
Iida, Takashi,Shinohara, Toshiyuki,Momose, Toshiaki,Tamura, Toshitake,Matsumoto, Taro,et al.
, p. 998 - 1004 (1986)
The complete set of the eight theoretically possible stereoisomeric 3,7,12-trihydroxy-5α-cholanic acids, five of which are new, were prepared by reduction of the four possible 3,7-dihydroxy-12-oxo-5α-esters.These esters, obtained by use of the inverting r
Potential Bile Acid Metabolites. 7. 3,7,12-Trihydroxy-5β-cholanic Acids and Related Compounds
Iida, Takashi,Chang, Frederic C.
, p. 2972 - 2978 (2007/10/02)
With this work, the complete set of the eight possible stereoisomeric (5β)-3,7,12-trihydroxy acids are now known and characterized.The key intermediates methyl 3α,7β-dihydroxy-12-oxo- and 3β,7β-dihydroxy-12-oxocholanate have been synthesized, and their reductions by tert-butylamine-borane complex and by NaBH4 are described.
