81882-64-6Relevant academic research and scientific papers
Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives
van Veldhoven, Jacobus P.D.,Campostrini, Giulia,van Gessel, Constantijn J.E.,Ward-van Oostwaard, Dorien,Liu, Rongfang,Mummery, Christine L.,Bellin, Milena,IJzerman, Adriaan P.
, (2020/12/07)
We synthesized and evaluated three novel series of substituted benzophenones for their allosteric modulation of the human Kv11.1 (hERG) channel. We compared their effects with reference compound LUF7346 previously shown to shorten the action po
