81886-49-9 Usage
Antifungal medication
Clotrimazole is used to treat a variety of fungal infections.
Mechanism of action
It disrupts the cell membranes of the fungi, leading to their death.
Common uses
Clotrimazole is commonly used to treat skin infections such as athlete's foot, jock itch, and ringworm, as well as vaginal yeast infections.
Available forms
It is available in various forms including creams, lotions, and troches for oral administration.
Side effects
Clotrimazole is generally well-tolerated, with common side effects including skin irritation and rash.
Contraindications
It may not be suitable for use in certain individuals, such as those with hypersensitivity to the drug or its components.
Check Digit Verification of cas no
The CAS Registry Mumber 81886-49-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,8,8 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 81886-49:
(7*8)+(6*1)+(5*8)+(4*8)+(3*6)+(2*4)+(1*9)=169
169 % 10 = 9
So 81886-49-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H13ClN6O/c14-12-3-1-11(2-4-12)13(21,5-19-9-15-7-17-19)6-20-10-16-8-18-20/h1-4,7-10,21H,5-6H2
81886-49-9Relevant academic research and scientific papers
Conversion of 4-amino-4H-1,2,4-triazole to 1,3-bis(1H-azol-1-yl)-2-aryl- 2-propanols and 1-phenacyl-4-[(benzoyl or 4-toluenesulfonyl)-imino]-(1H- 1,2,4-triazolium) ylides [1]
Narayanan,Chapman,Upadhyaya,Bauer
, p. 1405 - 1412 (2007/10/02)
A series of 1,3-bis(1H-azol-1-yl)-2-aryl-2-propanols 17 were synthesized in an one-pot procedure by reacting 1-aryl-2-(1H-1,2,4-triazol-1-yl)- or 1- aryl-2-(1H-imidazol-1-yl)ethanones with dimethylsulfoxonium methide in the presence of either 1,2,4-triazole or imidazole. The aromatic groups in 17 were either 4-bromo-, 4-chloro-, 2,4-dichloro- or 2,4-difluorophenyl. 4- Amino-4H-1,2,4-triazole was acylated with either benzoyl or 4-toluene- sulfonyl chloride to afford [4-(benzoyl or 4-toluenesulfonyl)amino]-4H- 1,2,4-triazole. Subsequent alkylations with 4-bromo- or 4-chlorophenacyl bromide produced 1-(4-bromo- or 4-chlorophenacyl)-4-[(benzoyl- or 4- toluenesulfonyl)amino]-1H-1,2,4-triazolium bromides. Neutralizations of these salts provided the corresponding ylides.
