819-46-5

Basic information

• Product Name: 4,4,4-TRIFLUOROBUTYLAMINE
• Synonyms: CF3CH2CH2CH2NH2;RARECHEM AL BW 1014;4,4,4-TRIFLUOROBUTYL-1-AMINE;4,4,4-TRIFLUOROBUTYLAMINE;4,4,4-Trifluorobutylamine 97%;4,4,4-Trifluorobutylamine97%;4,4,4-trifluorobutan-1-amine;1-Amino-4,4,4-trifluorobutane
• CAS NO: 819-46-5
• Molecular Formula: C₄H₈F₃N
• Molecular Weight: 127.11
• Mol File: 819-46-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 92-94
• Flash Point: 3.6 °C
• Appearance: Clear colorless/Liquid
• Density: 1.108 g/cm³
• Vapor Pressure: 148mmHg at 25°C
• Refractive Index: 1.345
• CAS DataBase Reference: 4,4,4-TRIFLUOROBUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4,4-TRIFLUOROBUTYLAMINE(819-46-5)
• EPA Substance Registry System: 4,4,4-TRIFLUOROBUTYLAMINE(819-46-5)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 819-46-5(Hazardous Substances Data)

Usage

General Description

4,4,4-Trifluorobutylamine is a chemical compound with the molecular formula C4H9F3N. It is a colorless and odorless liquid that is not soluble in water but is miscible with organic solvents. 4,4,4-TRIFLUOROBUTYLAMINE is primarily used as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a building block in the synthesis of other fluorinated compounds. 4,4,4-Trifluorobutylamine is known for its high reactivity and is a potential irritant to skin, eyes, and respiratory system. It is important to handle this chemical with care and in accordance with proper safety procedures.

InChI:InChI=1/C4H8F3N/c5-4(6,7)2-1-3-8/h1-3,8H2

Upstream product

• 101055-03-2 4-azido-1,1,1-trifluorobutane 
• 107-10-8 propylamine 
• 887144-94-7 Togni's reagent II 
• 461-18-7 4,4,4-trifluorobutanol 
• 461-34-7 4,4,4-trifluorobutyroamide 
• 56-12-2 4-amino-n-butyric acid 

Downstream Products

• 84153-82-2 4,4,4-trifluorobutan-1-amine hydrochloride 
• 1243325-58-7 3-nitro-4-(4,4,4-trifluorobutylamino)benzonitrile 
• 1589818-86-9 4-(2-methylthiazol-4-yl)-N-(4,4,4-trifluorobutyl)benzene sulfonamide 

Relevant articles and documents

The merger of decatungstate and copper catalysis to enable aliphatic C(sp 3)–H trifluoromethylation

The introduction of a trifluoromethyl (CF3) group can dramatically improve a compound’s biological properties. Despite the well-established importance of trifluoromethylated compounds, general methods for the trifluoromethylation of alkyl C–H bonds remain elusive. Here we report the development of a dual-catalytic C(sp3)–H trifluoromethylation through the merger of light-driven, decatungstate-catalysed hydrogen atom transfer and copper catalysis. This metallaphotoredox methodology enables the direct conversion of both strong aliphatic and benzylic C–H bonds into the corresponding C(sp3)–CF3 products in a single step using a bench-stable, commercially available trifluoromethylation reagent. The reaction requires only a single equivalent of substrate and proceeds with excellent selectivity for positions distal to unprotected amines. To demonstrate the utility of this new methodology for late-stage functionalization, we have directly derivatized a broad range of approved drugs and natural products to generate valuable trifluoromethylated analogues. Preliminary mechanistic experiments reveal that a ‘Cu–CF3’ species is formed during this process and the critical C(sp3)–CF3 bond-forming step involves the copper catalyst. [Figure not available: see fulltext.].

ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUND

The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.

Pyrimidine derivatives as IL-8 receptor antagonists

Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, —O—alkyl or —S-alkyl. A representative example is: