819-60-3

Usage

Uses

Used in Organic Synthesis:
N-(2,2,2-TRIFLUOROETHYL)UREA is used as a reagent in organic synthesis for its ability to facilitate the formation of desired chemical products. Its unique properties make it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In pharmaceutical research, N-(2,2,2-TRIFLUOROETHYL)UREA is utilized as a reagent to aid in the development and understanding of new drug candidates. Its role in this context is crucial for advancing the discovery of novel therapeutic agents.
Used in the Production of Pharmaceuticals:
N-(2,2,2-TRIFLUOROETHYL)UREA is used as an intermediate in the production of various pharmaceuticals. Its presence in the manufacturing process is essential for the synthesis of the final drug products.
Used in the Production of Agrochemicals:
Similarly, in the agrochemical industry, N-(2,2,2-TRIFLUOROETHYL)UREA is employed as an intermediate. It contributes to the development of agrochemicals that are vital for agricultural applications, such as pesticides and herbicides.
Safety Considerations:
It is important to handle N-(2,2,2-TRIFLUOROETHYL)UREA with care and follow proper safety protocols when working with it in a laboratory setting due to its potential hazards if not handled properly.

InChI:InChI=1/C3H5F3N2O/c4-3(5,6)1-8-2(7)9/h1H2,(H3,7,8,9)

Upstream product

• 590-28-3 potassium cyanate 
• 753-90-2 trifluoroethylamine 
• 373-88-6 2,2,2-trifluroethylamine hydrochloride 

Relevant academic research and scientific papers

A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation

We report a data-driven, physical organic approach to the development of new methionine-selective bioconjugation reagents with tunable adduct stabilities. Statistical modeling of structural features described by intrinsic physical organic parameters was applied to the development of a predictive model and to gain insight into features driving the stability of adducts formed from the chemoselective coupling of oxaziridine and methionine thioether partners through Redox Activated Chemical Tagging (ReACT). From these analyses, a correlation between sulfimide stabilities and sulfimide ν (C=O) stretching frequencies was revealed. We exploited the rational gains in adduct stability exposed by this analysis to achieve the design and synthesis of a bis-oxaziridine reagent for peptide stapling. Indeed, we observed that a macrocyclic peptide formed by ReACT stapling at methionine exhibited improved uptake into live cells compared to an unstapled congener, highlighting the potential utility of this unique chemical tool for thioether modification. This work provides a template for the broader use of data-driven approaches to bioconjugation chemistry and other chemical biology applications.

Ionic liquid mediated one-pot synthesis of 6-aminouracils

A novel, one-pot synthesis of 6-aminouracils via in situ generated ureas and cyanoacetylureas in the presence of an ionic liquid catalyst, 1,1,3,3-tetramethylguanidine acetate, is described. The catalyst can be recycled for five consecutive runs without loss of activity. The mechanism for the ring closure of cyanoacetylurea to 6-aminouracil is also discussed.