819067-17-9Relevant academic research and scientific papers
Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents
Elworthy, Todd R.,Brill, Emma R.,Chiou, San-San,Chu, Frances,Harris, Jason R.,Hendricks, R. Than,Huang, Jane,Kim, Woongki,Lach, Leang K.,Mirzadegan, Tara,Yee, Calvin,Walker, Keith A. M.
, p. 6124 - 6127 (2007/10/03)
Two distinct synthetic schemes were applied to access heteroatom-containing α-chain lactams or lactams terminated as aryl acids. The latter lactams were devised using a pharmacophore for EP4 receptor activity. γ-Lactams were characterized for their prostanoid EP receptor affinities and EP 4 activity and found to be selective for the EP2 and EP4 receptors or selective for the EP4 subtype. Benzoic acid 17 displayed enhanced in vivo exposure relative to 3.
