819075-21-3

Basic information

• Product Name: 2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine
• Synonyms: 2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine
• CAS NO: 819075-21-3
• Molecular Weight: 589.643
• Mol File: 819075-21-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine(819075-21-3)
• EPA Substance Registry System: 2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine(819075-21-3)

Safety Data

• Hazardous Substances Data: 819075-21-3(Hazardous Substances Data)

Upstream product

• 253873-19-7 2-(N,N-dimethylaminocarbonyloxymethyl)-1-(3,4,5-trimethoxybenzoyl)-4-(triphenylmethyl)piperazine 
• 253873-18-6 3-(N,N-diethylaminocarbonyloxymethyl)-1-(triphenylmethyl)piperazine 
• 530-57-4 3,5-dimethoxy-4-hydroxybenzoic acid 
• 253873-20-0 2-(N,N-diethylaminocarbonyloxymethyl)-1-(3,4,5-trimethoxybenzoyl)piperazine 

Relevant articles and documents

Structure-activity relationships in platelet-activating factor. Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity

HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. We previously reported that a trisubstituted piperazine derivative is able to diminish both HIV-1 replication in monocyte-derived macrophages and PAF-induced platelet aggregation. We report in this work new compounds obtained by modifying its piperazine substituents. The structure-activity relationship study shows that a better dual activity or even pure antiretroviral compounds can be obtained in this series.