81917-73-9

Upstream product

• 81917-69-3 N-(1-Benzotriazolylcarbonyl)-L-phenylalanin 
• 65095-13-8 1-benzotriazolecarboxylic acid chloride 
• 63-91-2 L-phenylalanine 

Downstream Products

• 845786-69-8 N-(1-benzotriazolecarbonyl)-L-phenylalanine pyrrolidineamide 
• 845786-67-6 N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexylamide 
• 845786-66-5 N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclopentylamide 
• 845786-68-7 N-(1-benzotriazolecarbonyl)-L-phenylalanine cyclohexanemethylamide 
• 845786-70-1 N-(1-benzotriazolecarbonyl)-L-phenylalanine diphenylmethylamide 
• 1248783-41-6 1-(1-(5-hydroxypentylcarbamoyl)-2-phenylethyl)-3-(5-hydroxypentyl)urea 
• 1248783-65-4 3-benzyloxy-5-benzylhydantoin 
• 1248783-54-1 N-(1-benzotriazolecarbonyl)-L-phenylalanine O-benzyloxyamide 
• 1248783-37-0 1-(1-(2-hydroxyethylcarbamoyl)-2-phenylethyl)-3-(2-hydroxyethyl)urea 
• 1248783-39-2 1-(1-(3-hydroxypropylcarbamoyl)-2-phenylethyl)-3-(3-hydroxypropyl)urea 
• 1248783-59-6 (S)-5-benzyl-3-hydroxyimidazolidine-2,4-dione 

Relevant academic research and scientific papers

Novel ureidoamides derived from amino acids: Synthesis and preliminary biological screening

A series of novel amino acid ureidoamides 4a-o were prepared from N-(1-benzotriazolecarbonyl)-amino acid chloride 3, derived from L-alanine, L-valine, L-leucine, D-phenylglycine and L-phenylalanine, and the corresponding aminoalcohols (2-amino-1-ethanol, 3-amino-1-propanol and 5-amino-1-pentanol). The compounds were fully characterized by standard spectroscopic methods (IR, 1H and 13C NMR) and their structure was confirmed by elemental analysis. Antioxidant screenings (interaction with 1,1-diphenyl-2-picrylhydrazyl, soybean lipoxygenase inhibition activity, inhibition of linoleic acid lipid peroxidation) revealed that the prepared compounds possessed only modest activity. On the other hand, no significant antiproliferative activity against five human cell lines and very weak antimicrobial activity against several bacteria and fungi were detected.

Hydantoin derivatives of L- and D-amino acids: Synthesis and evaluation of their antiviral and antitumoral activity

3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h were prepared by base induced cyclization of the corresponding N-(1- benzotriazolecarbonyl)-L-and D-amino acid amides 4a-h. Compounds 5a-h were evaluated for their cytostatic and antivi

The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: Synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations

The novel L- and D-amino acid derivatives of hydroxyurea 5a-o were prepared by aminolysis of N-(1-benzotriazolecarbonyl)amino acid amides 4a-o with hydroxylamine. The hydantoin derivatives 6a-e,m,p were synthesized by base-catalyzed cyclization of amides