81926-94-5

Basic information

• Product Name: ETHYLDOCOSAHEXAENOATE
• Synonyms: Doconexent [inn];(all-Z)-;(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid Ethyl Ester-d5;Docosahexanoic acid-[D5]-ethylester;(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid ethyl ester;Incromega DHA 700ESR;ethyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate
• CAS NO: 81926-94-5
• Molecular Formula: C₂₄H₃₆O₂
• Molecular Weight: 356.54
• Product Categories: Fatty Acid Derivatives & Lipids;Glycerols
• Mol File: 81926-94-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 443.5±24.0 °C(Predicted)
• Appearance: /
• Density: 0.914±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• CAS DataBase Reference: ETHYLDOCOSAHEXAENOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYLDOCOSAHEXAENOATE(81926-94-5)
• EPA Substance Registry System: ETHYLDOCOSAHEXAENOATE(81926-94-5)

Safety Data

• Hazardous Substances Data: 81926-94-5(Hazardous Substances Data)

Usage

Chemical Properties

Clear Colourless Oil

Definition

ChEBI: A long-chain fatty acid ethyl ester resulting from the formal condensation of the carboxy group of (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoic acid with the h droxy group of ethanol.

Upstream product

• 6217-54-5 docosahexaenoic acid 
• 64-17-5 ethanol 
• 122-51-0 orthoformic acid triethyl ester 
• 105-58-8 Diethyl carbonate 
• 98776-99-9 (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl chloride 
• 161794-74-7 (3Z,6Z)-nona-3,6-dienyl p-toluenesulfonate 
• 159145-96-7 Toluene-4-sulfonic acid (3Z,6Z)-8-(2,2-dimethyl-[1,3]dioxolan-4-yl)-octa-3,6-dienyl ester 
• 159145-99-0 Ethyl (Z,Z,Z)-13,14-O-Isopropylidenetetradeca-4,7,10-trienoate 
• 159145-91-2 1-(Tosyloxy)-5-hexen-2-yne 
• 159146-00-6 Ethyl (Z,Z)-13,14-Dihydroxytetradeca-4,7,10-trienoate 
• 159145-92-3 1-(Tetrahydropyranyloxy)dec-9-ene-3,6-diyne 
• 159145-95-6 (Z,Z)-9,10-O-Isopropylidenedeca-3,6-dien-1-ol 
• 159145-94-5 9,10-O-isopropylidenedeca-3,6-diyn-1-ol 
• 159145-93-4 Deca-4,7-diyne-1,2,10-triol 

Downstream Products

• 6217-54-5 docosahexaenoic acid 
• 10417-94-4 all cis-5,8,11,14,17-eicosapentaenoic acid 
• 98776-99-9 (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl chloride 
• 2566-90-7 all-cis-4,7,10,13,16,19-docosahexaenoic acid methyl ester 
• 121818-29-9 methyl 3-(3-((2Z,5Z,8Z,11Z,14Z)-heptadeca-2,5,8,11,14-pentaen-1-yl)oxiran-2-yl)propanoate 
• 162758-94-3 N-docosahexaenoylethanolamine 
• 1048012-06-1 (4Z,7Z,10Z,13Z,16Z,19Z)-N-(2,3-dihydroxypropyl)docosa-4,7,10,13,16,19-hexaenamide 
• 140670-40-2 (4Z,7Z,10Z,13Z,16Z,19Z)-Docosa-4,7,10,13,16,19-hexaenoic acid 2,3-dihydroxy-propyl ester 
• 1333067-15-4 (4Z,7Z,10Z,13Z, 16Z,19Z)docosa-4,7,10,13,16,19-hexaenoic acid [2-((4Z,7Z,10Z,13Z, 16Z,19Z)docosa-4,7,10,13,16,19-hexaenoylamino)ethyl]amide 
• 1282618-08-9 (4Z,7Z,10Z,13Z,16Z,19Z)-N-((R)-1-hydroxypropan-2-yl)docosa-4,7,10,13,16,19-hexaenamide 

Relevant articles and documents

Proline derivatives incorporating hydrophobic long-chain derived from natural and synthetic fatty acids

The α-hydrophobic long chain-α-amino esters are prepared by α-hydroxylation of a series of fatty acid esters [derived from oleic acid (OA), linoleic acid (LA), arachidonic acid (ARA) and docosahexaenoic acid (DHA)] followed by Mitsunobu reaction and hydrazinolysis of the phthalimide. These amino esters are mixed with aldehydes and electrophilic alkenes to give very good chemical yields and diastereoselectivities of prolinate derivatives incorporating a hydrophobic long chain at the α-position. This multicomponent 1,3-dipolar cycloaddition (1,3-DC) takes place at room temperature. The synthesis of the homologue hydrophobic chain of OA is performed by its oxidation to aldehyde/racemic N-tert-butylsulfinyl imine/Neff reaction. Final 1,3-DC with benzaldehyde and N-methylmaleimide affords homologue prolinate derivative in good yield.

METHODS OF PREPARING FREE POLYUNSATURATED FATTY ACIDS

Provided herein are methods of making compositions of free fatty acids and alkyl esters of polyunsaturated fatty acids (PUFAs). Also provided are compositions comprising a PUFA selected from a free fatty acid or a ester wherein the PUFA is made according to a method of the invention.

Process for the preparation of a composition comprising unsaturated compounds

The present invention relates to a process for the preparation of a composition comprising unsaturated compounds, in particular polyunsaturated compounds, which comprises concentrating and purifying the compounds by contact with silicon and/or aluminium derivatives. The process of the invention represents an advantageous substitute of the usual distillation processes, coupled or not to chromatographic processes, and allows to isolate and remove polar byproducts.