81931-99-9Relevant academic research and scientific papers
Synthesis and Reactivity of α-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [18F]ArylSCF3
Wu, Jiang,Zhao, Qunchao,Wilson, Thomas C.,Verhoog, Stefan,Lu, Long,Gouverneur, Véronique,Shen, Qilong
supporting information, p. 2413 - 2417 (2019/02/01)
A highly reactive electrophilic bromodifluoromethylthiolating reagent, α-cumyl bromodifluoro-methanesulfenate 1, was prepared to allow for direct bromodifluoromethylthiolation of aryl boron reagents. This coupling reaction takes place under copper catalysis, and affords a large range of bromodifluoromethylthiolated arenes. These compounds are amenable to various transformations including halogen exchange with [18F]KF/K222, a process giving access to [18F]arylSCF3 in two steps from the corresponding aryl boronic pinacol esters.
(Bromodifluoromethyl)thioxo compound, intermediate as well as preparation method and application of compound
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Paragraph 0100-0102, (2017/09/01)
The invention discloses a (bromodifluoromethyl)thioxo compound, an intermediate as well as a preparation method and application of the compound. The invention provides a compound I, wherein R1, R2 and R3 are respectively independently H, C1-C10 alkyl and C6-C10 aryl, and at least two of R1, R2 and R3 are not H at the same time; any two of R1, R2 and R3 are connected to form a C3-C6 cycloalkane; or any two of R1, R2 and R3 are connected to from a C3-C6 cycloalkane, and then the C3-C6 cycloalkane and a benzene ring form a parallel loop. The preparation method of the compound I provided by the invention comprises the following step: in an organic solvent, carrying out reaction on a compound II, Cl2 and a compound III, so that the compound I is obtained. By adopting the (bromodifluoromethyl)thioxo compound I, direct introduction of (bromodifluoromethyl)thio on an aromatic hydrocarbon or hetero-aromatic hydrocarbon compound can be realized. (The structure of the compound I is described in the specification.).
Electrophilic difluoro(phenylthio)methylation: Generation, stability, and reactivity of α-fluorocarbocations
Betterley, Nolan M.,Surawatanawong, Panida,Prabpai, Samran,Kongsaeree, Palangpon,Kuhakarn, Chutima,Pohmakotr, Manat,Reutrakul, Vichai
supporting information, p. 5666 - 5669 (2013/12/04)
Electrophilic difluoro(phenylthio)methylation of allylsilanes has been achieved using bromodifluoro(phenylthio)methane (PhSCF2Br) and silver hexafluoroantimonate (AgSbF6). The structural assignment and observation of α-fluorocarbocation were substantiated by NMR and theoretical calculations. Detailed mechanistic and electronic studies have provided a fundamental understanding of the reactivity and stability of the difluoro(phenylthio)methylium cation (PhSCF2+).
SYNTHESE DE COMPOSES AROMATIQUES COMPORTANT LES GROUPEMENTS OCF2Br ET SCF2Br-II; ACTION DE CF2Br2 ET DE CF2BrCl SUR DES THIOPHENATES ET PHENATES DE POTASSIUM DIVERSEMENT SUBSTITUES
Rico, I,Wakselman, C.
, p. 4209 - 4214 (2007/10/02)
The reaction of dibromodifluoromethane and bromochlorodifluoromethane with substituted potassium thiophenoxides and phenoxides leads to the formation of new aromatic compounds bearing OCF2Br and SCF2Br groups.
